Objectives: This study aimed to investigate the association between pubic and external genitalia hair removal by laser devices and human papillomavirus (HPV) infection.

Materials and Methods: In this study, a total of 809 women were examined. To this end, 250 women with HPV-positive and 500 ones with HPV-negative/normal cytology were assigned to two groups. Then these women were demographically matched, and the two groups were compared regarding the prevalence of laser device usage for external genital hair removal. Finally, the statistical analysis was performed using unpaired student t-test and Kolmogorov-Smirnov test.

Results: The prevalence of laser hair removal were 59% and 25% in HPV-positive and HPV-negative/regular cytology groups, respectively. It was found that the history of laser hair removal was positively associated with positive HPV results (OR: 4.353, CI: 95%, 3.157 to 5.989).

Conclusions: Laser hair removal was positively associated with positive HPV transmission. However, it was recommended that further studies with greater sample sizes should be carried out to determine if the pubic hair removal by laser devices increased the HPV transmission risk.