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Jul 2024, Vol 12, Issue 3
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Original Article
Effects of Cornus mas Extract (Anthocyanin) and Treadmill Exercise on Hormonal and Histological Effects in the Rat Model of Polycystic Ovary Syndrome
Ramesh Baradaran Bagheri1, Negin Chavoshinezhad2, Bita Barghi2, Maryam Soleymaniinallou3, Majid Shokoohi4, Peyman Najafnezhad4, Amir Afshin Khaki2, Farnaz Dabiri4
1Department of Obstetrics and Gynecology, Faculty of Medicine, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran
2Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Pharmacy, Faculty of Pharmacy, University of Health Sciences, Istanbul, Turkey
4Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

DOI: 10.15296/ijwhr.2024.6004
Viewed : 333 times
Downloaded : 343 times.

Keywords : Cornus mas, PCOS, Hormones, Ovary, Rat
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Abstract

Objectives: This study aimed to assess the protective impact of Cornus mas extract and treadmill exercise on hormonal and metabolic parameters in adult rats with polycystic ovary syndrome (PCOS).

Materials and Methods: Forty female Wistar rats were divided into control and experimental groups. The experimental group was further divided into 5 subgroups, namely PCOS control group (G1), PCOS group treated with C. mas extract (100 mg/kg/orally/daily) (G2), PCOS group treated with scheduled treadmill exercise (G3), PCOS group treated with both extract and exercise (G4), and PCOS group treated with C. mas extract and treadmill exercise (G5). PCOS was induced in G1 by a single injection of estradiol valerate (16 mg/kg, IM). After a 3-week treatment period, all rats were anesthetized and their blood samples were collected for testing the levels of glucose, insulin, aromatase, and hormones (LH, FSH, testosterone, and estrogen). Then their ovaries were removed for histopathological examination.

Results: Serum levels of FBS, insulin, luteinizing hormone [LH], follicle-stimulating hormone [FSH], and testosterone were significantly increased in PCOS compared to the control group (P<0.05); however, these levels were significantly decreased in the treated groups compared to PCOS (P<0.05). Serum estrogen levels and aromatase activity were significantly decreased in PCOS compared to the control (P<0.05); however, they were significantly increased in the treated groups compared to PCOS (P<0.05). PCOS led to a reduction in the number of follicles, which was prevented by C. mas extract.

Conclusions: In sum, C. mas extract and treadmill exercise had a positive impact on LH, FSH, testosterone, estradiol, aromatase, FBS, and insulin levels compared to the PCOS group.

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Articles by Chavoshinezhad N
Articles by Barghi B
Articles by Soleymaniinallou M
Articles by Shokoohi M
Articles by Najafnezhad P
Articles by Afshin Khaki A
Articles by Dabiri F

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Articles by Bita Barghi
Articles by Majid Shokoohi
Articles by Peyman Najafnezhad
Articles by Amir Afshin Khaki
Articles by Farnaz Dabiri

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