|Non-endometrioid Synchronized Endometrial and Ovarian Carcinoma: Report of Two Rare Cases
|Soheila Aminimoghaddam1, Elham Saffarieh2, Pegah Kamkarfar3, Mahsa Kiani3, Parinaz Hamednasimi3
|1Department of Obstetrics and Gynecology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
2Abnormal Uterine Bleeding Center of Semnan University of Medical Sciences, Semnan, Iran
3Endometriosis Research Centers of Iran University of Medical Sciences, Tehran, Iran
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Keywords : Papillary serous carcinoma, Clear cell carcinoma, synchronized endometrial, Ovarian cancer
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Objectives: Synchronized endometrial and ovarian cancer (SEOC) is a condition in which there is both primary endometrial and primary ovarian cancer at the same time in a patient. These tumors have a better prognosis than metastatic ones. Most of them are diagnosed in the early stages and are low-grade tumors. So differentiation of this kind of rare tumor from others is essential. No adjuvant chemotherapy seems to be reasonable in cases with low-grade tumors both in endometrioid and non-endometrioid types. High-grades tumors have been described less, but, in some studies, genetic mutations were found in these tumors, which have been the basis of targeted therapy after surgery.
Case Presentation: In this report, two rare non-endometrioid types of SEOC cases are discussed. The first case is a low-grade papillary serous carcinoma of the ovary and uterus endometrium. In contrast, the second case is a clear cell carcinoma of the ovary and endometrioid adenocarcinoma of the uterus. We also review the literature in this field.
Conclusion: We conclude that in these cases, chemotherapy with routine regimens does not seem to be helpful in early stages with low-grade tumors. Also, in high-grade tumors, targeted therapy may be more effective than adjuvant chemotherapy.
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