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Apr 2015, Vol 3, Issue 2
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Original Article
Diagnostic Modalities in Premature Rupture of Membranes
Fatma Eskicioğlu1, Esra Bahar Gur2
1Department of Obstetrics and Gynecology, School of Medicine, Celal Bayar University, Manisa, Turkey
2Department of Obstetrics and Gynecology, School of Medicine, Sifa University, Izmir, Turkey

IJWHR 2015; 3: 089-092
DOI: 10.15296/ijwhr.2015.17
Viewed : 4816 times
Downloaded : 9926 times.

Keywords : Fetal membranes, Insulin-like growth factor binding protein 1, Placental alpha-microglobulin 1, Premature rupture
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Objectives: Rupture of membranes prior to the onset of labor is known as Premature Rupture of Membranes (PROM). Early and correct diagnosis is crucial in order to prevent fetal and maternal risks that can be life threatening. We aimed to investigate the diagnostic ability of the tests in PROM.

Materials and Methods: Nitrazine test, fern test, amnio-dye test, biochemical tests (insulin-like growth factor binding protein-1 and placental alpha microglobulin-1) were evaluated in terms of effectiveness in diagnosis of PROM.

Results: A gold standard method has not yet been defined in PROM. Diagnostic tests (nitrazine test, fern test, Insulin-like Growth Factor Binding Protein-1 ?IGFBP-1? and Placental Alpha Microglobulin-1 ?PAMG-1?) should be used when the diagnosis is not certain following history, examination with sterile speculum and ultrasonography evaluation.

Conclusion: IGFBP-1 and PAMG-1 are tests based on bedside immunochromatographic method. Especially, PAMG-1 comes into prominence with its high sensitivity and specificity.

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