|The Effect of Herbal Medicine Supplementation on Clinical and Para-clinical Outcomes in Women With PCOS: A Systematic Review and Meta-analysis|
|Nava Ainehchi1, Azizeh Farshbaf-Khalili2, Aliyeh Ghasemzadeh1, Kobra Hamdi1, Arash Khaki1, Elaheh Ouladsahebmadarek1, Abbas Delazar3, Fahimeh Bakhtyari2, Masoumeh Mazandarani4|
|1Women?s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Aging Research Institute, Physical Medicine and Rehabilitation Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
3Research Center for Evidence based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Botany, Gorgan Branch, Islamic Azad University, Gorgan, Iran
IJWHR 2019; 7: 423?433
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Keywords : Polycystic ovary syndrome, Zingiber officinale, Mentha spicata, Cinnamomum zeylanicum Nees, Medicinal herb
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Objectives: The aim of this study is to assess the impact of Cinnamomum verum, Mentha spicata, Zingiberene officinal on polycystic ovary syndrome (PCOS) treatment.
Materials and Methods: MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Scopus, Web of Science, Google Scholar, ProQuest, Clinicaltrial.gov, and for Persian articles SID, Magiran, Irandoc, and Iranmedex were searched without any time limitation.
Results: Thirteen randomized controlled trials (RCTs) consisting 668 women were entered in the meta-analysis. Significant differences in fasting blood sugar (FBS; weighted mean difference (WMD)=-3.69 mg/dL, 95% CI: -6.67 to -0.7, P = 0.02; 241 participants), fasting insulin (WMD = -4.53 ?IU/mL, 95% CI: -6.45 to -2.61, P < 0.001;183 participants), triglyceride (TG; WMD = -17.97 mg/dL, 95% CI: -30.51 to -5.43, P = 0.005;183 participants), total cholesterol (TC; WMD=-14.60 mg/dL, 95% CI: -22.93 to -6.26, P = 0.0006; 183 participants), low-density lipoprotein cholesterol (LDL; WMD = -16.58 mg/dL, 95% CI -23.91 to -9.24, P < 0.001; 183 participants), malondialdehyde (MDA; WMD = -0.25 nmol/ml, 95% CI -0.41 to -0.09, P < 0.002;124 participants), total testosterone (TT; WMD = -0.18 ng/mL, 95% CI -0.27 to -0.09, P < 0.001; 116 participants), free testosterone (FT; WMD = -5.47 pg/mL, 95% CI -8.34 to -2.61, P = 0.0002;78 participants) were obtained by using cinnamon alone and herbal mixture containing cinnamon in comparison to control.
Conclusions: This meta-analysis showed that cinnamon alone and herbal mixture containing cinnamon improve level of FBS, fasting insulin, TG, TC, LDL, MDA, TT, and FT serum level.
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