Materials and Methods: The present cross-sectional study included 105 Iranian women with BPH-afflicted spouses. Data were collected using the Female Sexual Functional Index (FSFI), International Prostate Symptoms Score (IPSS), and International Index of Erectile Function (IIEF). Multiple regression was analyzed using SPSS 20 software.

Results: The mean age of women and their husbands was 55.41 ± 14.19 and 61.82 ± 12.22, respectively. As revealed by the results of the multiple linear regression, the variables of female’s age (B = -0.266, P < 0.001), male’s educational level (B = 3.914, P = 0.004), female’s sleep disorder (B = 3.780, P = 0.033), The storage symptom of IPSS (IPSS-S) (B = -0.510, P = 0.005) and IIEF Erectile Function sub-score (IIEF-EF) (B= 4.553, P < 0.001) were the final predictors of their “women’s sexual function”. (R2 =0.595, ADJ. R2 = 0.579, R = 0.772).

Conclusions: The results of the present study confirm the negative effect of BPH on women’s sexual function. Given that, the variables of female’s age and male’s educational level from the socio-demographic factors, female’s sleep disorder from the factors related to BPH, IPSS-S from the IPSS and IIEF-EF from the IIEF were the final predictors of “women’s sexual function.” Therefore, the condition of men’s disease has a significant impact on their spouses’ sexual function, and thus, it is necessary to support and pay attention to the spouses of patients. In addition, it is essential to incorporate the concept of women’s sexual health with BPH-afflicted husbands into health providers’ retraining programs.