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Jul 2023, Vol 11, Issue 3
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Original Article
The Regulatory Effect of Eugenol on FSHR, LHCGR, and ER Expression during Follicular Development in Female Rats With Ovarian Torsion
Ramesh Baradaran Bagheri1, Seyedeh Sara Salami2, Linda Mohammadzadeh Boukani2, Amir Afshin Khaki3
1Department of Obstetrics and Gynecology, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran
2Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

IJWHR 2023; 11: 138-144
DOI: 10.15296/ijwhr.2023.24
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Keywords : Ovarian torsion, LHCGR, FSHR, Eugenol
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Abstract
Objectives: This study aimed to investigate the role of Eugenol in regulating the expression of FSH receptor (FSHR), human luteinizing hormone choriogonadotropin receptor (LHCGR), and estrogen receptor (ER) during follicular development in female rat ovarian torsion.

Materials and Methods: In this experimental study, 48 female rats were randomly assigned to 4 groups, including G1 (i.e., sham), G2 (i.e., ovarian torsion/detorsion group), G3 (i.e., ovarian torsion/detorsion group treated with 30 mg/kg of eugenol), G4 (i.e., healthy group treated with 30 mg/kg of eugenol). After covering a treatment period of ten days, the ovarian tissue was collected for the histological analysis, the measurement of ER, FSHR, and LHCGR expression, as well as the assessment of testosterone, LH, FSH, and estrogen levels in blood serum.

Results: Histological evaluation revealed the damage to ovarian tissue, the reduced oocyte, and the granulosa cell diameter in the torsion/detorsion group. However, the treatment with eugenol mitigated this damage. Eugenol administration increased the levels of estrogen, LH, and FSH, but it decreased the testosterone levels in the treated group. Moreover, the expression of ER, FSHR, and LHCGR was upregulated in the treated groups. Administration of eugenol was associated with an enhanced fertility.

Conclusions: It was concluded that eugenol administration may have been effective in protecting the ovarian tissue from the damage caused by torsion/detorsion. Furthermore, eugenol was found to have the potential to modulate hormonal profiles and regulate the expression of ER, FSHR, and LHCGR, thereby contributing to an increased fertility.

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