Login Contact Us
Oct 2022, Vol 10, Issue 4
Advanced Search
How do you find the scientific quality of the published articles on our web site?

Original Article
Chemotherapy-Related Structural Changes in Cancer: Effect of GnRH Antagonist in the Ovarian Follicles
Daryosh Mohammadnejad1, Faeze Daghigh2, Arezou Hamzehzadeh3
1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Physiology, Faculty of Medicine, Tabriz Medical sciences, Islamic Azad University, Tabriz, Iran
3Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran

IJWHR 2022; 10: 214-218
DOI: 10.15296/ijwhr.2022.36
Viewed : 1845 times
Downloaded : 2089 times.

Keywords : Chemotherapy, Gonadotropin-releasing hormone, Follicle-stimulating hormone, Luteinizing hormone, Thiotepa
Full Text(PDF) | Related Articles
Objectives: The adverse effect of chemotherapy on the proliferation of granulosa cells has been indicated in recent studies. Gonadotropin-releasing hormone (GnRH) antagonists exert protective effects on granulosa cells against the side effects of chemotherapy. In the present study, we aimed to evaluate the impact of cetrorelix on the proliferation of ovarian granulosa cells following administration of thiotepa in the ovaries of female mice.

Materials and Methods: In this experimental study, 30 adult Balb/c female mice (5-8 weeks old, weighing 24-28 g) were divided into three groups (n=10/ each group) (Control group, T. group, and C. group). T. group received 2.5 mg/kg of thiotepa for four consecutive days. The C. group received cetrorelix (0.25 mg/kg) before and at the same time as thiotepa administration and a week after the end of thiotepa administration. Ovaries were used for quantitative and immunohistochemical studies at the end of the investigation.

Results: The mean numbers of follicles such as primordial, primary, secondary, and tertiary significantly decreased in the T. group than control group (P = 0.02). Cetrorelix treatment exerted a protective effect against thiotepa-induced damage by increasing the mean numbers of follicles in the ovarian cortex (P = 0.04).

Conclusions: As a GnRH antagonist, cetrorelix can be considered as one of the effective drugs to protect the granulosa cells against chemotherapy-induced damages in cancer disease.

Cite By, Google Scholar

Google Scholar

Articles by Mohammadnejad D
Articles by Daghigh F
Articles by Hamzehzadeh A


Articles by Faeze Daghigh
Articles by Arezou Hamzehzadeh

Submit Paper
Online Submission System
IJWHR ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Published Article Statistics