|Effect of Vitex agnus-castus and Salvia officinalis Extracts on Serum Lipids in Postmenopausal Women: An Randomized Clinical Trial|
|Afsaneh Zeidabadi1, Maryam Jafari1, Masoumeh Emamghoreishi2, Mohammad Resa Sasani3, Marzieh Akbarzadeh4|
|1School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Radiology, Medical Imaging Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Maternal-Fetal Medicine Research Center, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
Keywords : Vitex agnus-castus, Salvia officinalis, Lipoproteins, LDL, HDL, Triglycerides, Lipids, Postmenopausal, Women
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Objectives: This study aimed to investigate the effect of Vitex agnus-castus (VAC), and Salvia officinalis extracts on serum lipids in postmenopausal women referred to the Bone Densitometry Center, Namazi Hospital, Shiraz, Iran.
Materials and Methods: This randomized clinical trial was conducted on 89 postmenopausal women in 2016 using random permuted blocks with a block size of 3 in the three groups, including the VAC group (3.2-4.8 mg/q8h), S. officinalis group (100 mg/q8h), and placebo group for three months. Women were finally compared in terms of low-density lipoprotein, triglycerides (TG), and high-density lipoprotein before and after the intervention. Data were analyzed using SPSS-16 software. Descriptive statistical tests and paired t test were used to compare the groups.
Results: A significant decrease in serum cholesterol, low-density lipoprotein, and triglycerides levels and also increase in mean serum high-density lipoprotein levels were observed in VAC and S. officinalis groups before and after the intervention (P = 0.0001). In comparison, no significant change was observed in serum level of any lipoproteins in the placebo group.
Conclusions: Considering the decrease in the level of cholesterol, low-density lipoprotein, triglycerides, and increased high-density lipoprotein after using VAC and S. officinalis in this study, these herbs can be proposed as blood lipid-lowering agents in postmenopausal women.
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