International Journal of Women's Health and Reproduction Sciences

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Jul 2021, Vol 9, Issue 3

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Original Article
Alterations of Uterine Blood Flow During the Follicular Phase in Patients With Recurrent Implantation Failure: A Doppler Ultrasonographic Study
Marjan Amini¹, Mahnaz Ranjkesh², Saba Nikanfar³, Amir Fattahi⁴, Laya Farzadi¹, Kobra Hamdi¹
¹Women’s Reproductive Health Research Center, Alzahra hospital, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Obstetrics and Gynecology, Tabriz University of Medical Science, Tabriz, Iran ²Medical Radiation Sciences Research Group, Tabriz University of Medical Sciences, Tabriz, Iran ³Department of Biochemistry and Clinical Laboratories, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran ⁴Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
IJWHR 2021; 9: 217-221 DOI: 10.15296/ijwhr.2021.40 Viewed : 2163 times Downloaded : 2248 times. Keywords : Transvaginal Doppler ultrasound, Implantation failure, Uterine blood flow
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Abstract

Objectives: The dynamics of blood flow in the endometrium plays a crucial role during the implantation process. This study aimed to assess the uterine perfusion during the follicular phase in patients with a history of recurrent implantation failure (RIF) and healthy fertile women using the transvaginal ultrasound color Doppler method. Materials and Methods: To this end, 50 patients with RIF and 50 age-matched healthy fertile women were recruited in this case-control study. The transvaginal color Doppler ultrasonography was used to evaluate the pulsatility index (PI) and resistance index (RI) of the uterine, arcuate, and sub-endometrial arteries during the follicular phase in both groups. Results: The RI and PI of both right and left uterine arteries were higher in the RIF group compared to the fertile women (P<0.05). Our results showed that the PI and RI of sub-endometrial blood flow and the RI of arcuate arteries were substantially higher in the group with a history of RIF in comparison with the control group. However, the PI of arcuate arteries was not significantly different between the groups. Conclusions: Adequate uterine perfusion and sub-endometrial blood flow are necessary to achieve successful implantation and pregnancy since our results demonstrated the higher resistance of uterine and sub-endometrial arteries in patients with a history of RIF. Thus, the assessments of uterine perfusion indices during the follicular phase could be used as a non-invasive method in the evaluation of patients with RIF.