Login Contact Us
Apr 2023, Vol 11, Issue 2
Advanced Search
Title
Authors
Keyword
Poll
How do you find the scientific quality of the published articles on our web site?


Original Article
Association of Cell-Free Fetal DNA at 11-17 Weeks of Pregnancy and the Outcome of Pregnancy
Sedigheh Borna, Azam Tarafdari, Hedyeh Khenar, Amirhossein Zabolian, Ava Ajir, Shima Mohammadi, Ali Hosseini
Department of Obstetrics and Gynecology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

IJWHR 2023; 11: 089-092
DOI: 10.15296/ijwhr.2023.15
Viewed : 4063 times
Downloaded : 2852 times.

Keywords : Cell-free fetal DNA, Pregnancy outcomes, Non-invasive prenatal screening
Full Text(PDF) | Related Articles
Abstract
Objectives: This study aimed to evaluate the association between cell-free fetal DNA (cffDNA) levels in the first and second trimesters and adverse pregnancy outcomes.

Materials and Methods: This was a retrospective cohort study including all women who had cffDNA measurement as a primary or secondary screening test for chromosomal abnormalities in a screening laboratory in Iran.

Results: Totally, 481 out of 634 pregnant women (75.9%) did not develop any pregnancy complications. On the other hand, 55 pregnancies (8.7%) led to preterm delivery. Based on the results, 33 pregnant women (5.2%) gave birth to intrauterine growth restriction (IUGR) babies and 16 pregnant women (2.52%) developed preeclampsia (PE). Moreover, 15 women developed gestational diabetes. Further, 11 pregnancies resulted in abortion and 6 pregnancies led to fetal death. There was a positive association between the duration of pregnancies and the weight of the babies at birth (r = 0.362, P = 0.000). There was a statistically significant association between the increase in cffDNA level and trisomy (P = 0.000) and the decrease in cffDNA level and the incidence of PE (P=0.019).

Conclusions: The reduction of plasma cffDNA level in pregnancies led to PE and the elevation of cffDNA results in fetal trisomy. However, further studies will be required to confirm these findings.

Cite By, Google Scholar

Google Scholar

Articles by Borna S
Articles by Tarafdari A
Articles by Khenar H
Articles by Zabolian A
Articles by Ajir A
Articles by Mohammadi S
Articles by Hosseini A

PubMed

Articles by Sedigheh Borna
Articles by Azam Tarafdari
Articles by Hedyeh Khenar
Articles by Ava Ajir
Articles by Shima Mohammadi
Articles by Ali Hosseini

Submit Paper
Online Submission System
IJWHR ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Published Article Statistics