|The Effect of Multivitamins, Minerals, and Q10 on Precancerous Lesions of the Cervix|
|Mitra Modarres Gilani1, Azam Sadat Mosavi1, Setare Akhavan1, Mehrangiz Zamani2, Mohammad Ali Mohsenpour3,4, Fatemeh Mohsenpour2, Azar Pir Dehghan2, Danial Farhadi2, Fazezeh Torkzaban2|
|1Department of Obstetrics and Gynecology, Emam Hospital, Tehran University of Medical Sciences and Health Services, Tehran, Iran
2Department of Obstetrics and Gynecology, Fatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran
3Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
4Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
IJWHR 2021; 9: 280-283
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Keywords : Precancerous, Dietary supplement, Q10, Cervix, Colposcopy
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Objectives: Invasive cervical cancer is one of the most fatal genital cancers of women which can be detected by having Pap smear in precancerous stage. Various approaches can be taken for treating or preventing the progress of these precancerous lesions. The aim of this study was to investigate the cytopathological and colposcopic response of precancerous lesions to multivitamin, mineral (multi-mineral), and coenzyme Q10 supplements.
Materials and Methods: The present randomized clinical trial was conducted on 120 participants with clinical complaints or abnormal Pap smear test results. The intervention and control groups received supplemental and placebo treatments, respectively, for 3 months after a primarily Pap smear test. The Pap smear test was also performed after the treatment and patients with abnormal results were screened by colposcopy. Data were analyzed by SPSS software and P-value less than 0.05 was considered significant.
Results: The percentage of participants in the intervention and control groups were 40% and 28.3% in the age range of 20-29, 26.7% and 41.7% in the age range of 30–39, and finally 33.3% and 30% over 40 years of age, respectively (P = 0.19). The percentage of normalization in Pap smear test result was 83.3% and 53.3% in the intervention and control groups, respectively (P < 0.001).
Conclusions: It was found that short-term usage of multi-mineral and Q10 supplements may decrease the risk of cervical cancer in women with abnormal Pap smear. However, studies with larger population and longer trial period are needed for further investigation.
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