International Journal of Women's Health and Reproduction Sciences

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Jul 2014, Vol 2, Issue 4

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Original Article
Does Ovulation Induction Increase the Risk of Aneuploid Conception? Comparison of First Trimester Miscarriages after FSH Stimulated Cycles and Naturally Conceived Cycles
Celtemen Pinar Telli¹, Erdem Mehmet¹, Bozkurt Nuray¹, Meral Yirmibes², Oktem Mesut¹, Erdem Ahmet¹, Karabacak Onur¹ , Celtemen Mustafa Baran³, Kayhan Gülsüm²
¹Department of Obstetrics and Gynecology, Gazi University, Faculty of Medicine, Ankara, Turkey ²Department of Medical Genetics, Gazi University, Faculty of Medicine, Ankara, Turkey ³Department of Obstetrics and Gynecology, Cankiri Government Hospital, Cankiri, Turkey
IJWHR 2014; 2: 225–228 DOI: 10.15296/ijwhr.2014.32 Viewed : 5219 times Downloaded : 3750 times. Keywords : Aneuploidy, IVF, Miscarriage, Menarche, Ovulation Induction
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Abstract

Objective: The aim of this study was to determine the rate of chromosomal abnormalities in the products of first trimester miscarriages in patients who were under FSH ovarian stimulation and to compare the results with the products of miscarriages of naturally conceived pregnancies. Materials and Methods: This retrospective cohort study was conducted over a nine-year period. Included were 909 patients who conceived naturally and 76 infertility patients who were under FSH stimulation with first trimester miscarriages karyotyped. The rate of aneuploidy was compared between the two groups. The main outcome measure was the incidence of aneuploidy. Results: In 76 FSH-induced pregnancies, 12 (15.7%) had an abnormal karyotype. The rate of aneuploidy rate in miscarriages in the natural conception group was 22.3%. There was no statistically significant difference in age (32.7 ± 4.2 vs. 33.5 ± 5.0), cycle day 3 FSH (7.9 ± 2.3 mIU/ml vs. 7.1 ± 2.6 mIU/ml) or exogenous FSH doses (2419.7± 643.7 IU vs. 2616.5 ± 947.5 IU) between the infertile patients with or without abnormal karyotypes. Conclusion: Exposure to exogenous FSH was not associated with increased aneuploidy rates in our infertile population.