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Jan 2021, Vol 9, Issue 1
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Original Article
Demographic, Anthropometric, and Biochemical Characteristics of Jordanian Women With Polycystic Ovary Syndrome: A Case-Control Study
Jehan Hamadneh1, Nahla S. Al-bayyari2, Shereen Hamadneh3, Safaa Al-Zeidaneen4, Hadil Subih2, Samar Z. Burgan5, Zouhair O. Amarin1
1Department of Obstetrics and Gynaecology, Faculty of Medicine, Jordan University of Sciences and Technology, Irbid, Jordan
2Department of Nutrition and Food Technology, Al-Huson University College, Al-Balqa Applied University, Irbid, Jordan
3Department of Maternal and Child Health, Faculty of Nursing, Al-albayt University, Mafraq, Jordan
4Department of Allied Medical Sciences, Faculty of Al-Zarqa University College, Al-Balqa Applied University, Al-Salt, Jordan
5Department of Oral and Maxillofacial Surgery, Oral Medicine and Periodontology, School of Dentistry, the University of Jordan, Amman, Jordan

IJWHR 2021; 9: 024-028
DOI: 10.15296/ijwhr.2021.05
Viewed : 575 times
Downloaded : 462 times.

Keywords : Polycystic ovary syndrome, Homocysteine, Androgens, Lipids
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Abstract
Objectives: To compare the demographic, anthropometric, and biochemical characteristics between women with polycystic ovary syndrome (PCOS) and healthy women and to identify the independent biochemical markers of PCOS.

Materials and Methods: A case-control study was conducted on 77 women with PCOS and 73 healthy controls aged between 18 and 49 years. Blood samples were obtained for the determination of plasma total homocysteine (tHcy), total cholesterol (TC), triglycerides (TG), low- and high-density lipoprotein, TC/high-density lipoprotein ratio, total testosterone (TT), sex hormone-binding globulin, and free androgen index (FAI). Finally, multivariable logistic regression analysis was performed to identify the independent biochemical markers of PCOS.

Results: The mean differences between cases and controls in tHcy, TG, and sex hormone-binding globulin were statistically significant. tHcy and TG were elevated in cases while sex hormone-binding globulin demonstrated a reduction. All three markers were identified as independent predictors of PCOS in multivariable analysis in addition to a fourth, TT. tHcy is an independent biomarker of PCOS despite a relationship with TG and TC, the former of which is itself an independent biomarker.

Conclusions: In general, overweight women with PCOS had higher levels of tHcy and TG and a lower level of sex hormone-binding globulin compared with healthy controls. The level of tHcy is a marker of PCOS independent of the lipid profile. The differential biochemical profile of women with PCOS and healthy women provides useful hints for the diagnosis of PCOS and thus must be addressed in relation to the risk of cardiovascular disease.

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Articles by Hamadneh J
Articles by S. Al-bayyari N
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Articles by Al-zeidaneen S
Articles by Subih H
Articles by Z. Burgan S
Articles by O. Amarin Z

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Articles by Jehan Hamadneh
Articles by Shereen Hamadneh
Articles by Safaa Al-Zeidaneen
Articles by Hadil Subih
Articles by Samar Z. Burgan
Articles by Zouhair O. Amarin

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