|Are the Circulating Levels of Copeptin and Fibronectin Dysregulated in Preeclamptic South African Black Women?|
|Kayshia Deepnarain1, Thajasvarie Naicker2, Sapna Ramdin1, Poovendhree Reddy3, Nalini Govender1|
|1Department of Basic Medical Sciences, Faculty of Health Sciences, Durban University of Technology, Durban, South Africa
2Discipline of Optics and Imaging, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
3Department of Community Health Studies, Faculty of Health Sciences, Durban University of Technology, Durban, South Africa
IJWHR 2021; 9: 149-152
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Keywords : Pregnancy, Preeclampsia, Copeptin, Fibronectin
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Objectives: To establish the circulating levels of copeptin and fibronectin in normal and preeclamptic Black South African pregnant females.
Materials and Methods: Serum copeptin and fibronectin levels were measured in preeclamptic and normotensive women via enzyme-linked immunosorbent assays. Data are presented as medians and interquartile ranges. Spearman’s chi-square test was used to evaluate bivariate associations between analytes and clinical variables.
Results: Fibronectin levels were downregulated in preeclampsia (PE) compared to the control group (P < 0.05). Copeptin levels displayed an upward trend in PE compared to the normotensive group. Blood pressure (systolic and diastolic) was significantly different between preeclamptic and normotensive women (P < 0.005). In the preeclamptic group, gestational age was negatively correlated with systolic blood pressure (r = -0.8, P < 0.05). In addition, diastolic blood pressure was negatively correlated with maternal weight (r=-0.58, P < 0.05) and gestational age (r = -0.76, P < 0.05) in the preeclamptic group. Eventually, a positive correlation was noted between diastolic blood pressure and systolic blood pressure (r = 0.65, P < 0.05) in PE.
Conclusions: This was the first South African study to measure copeptin and fibronectin in pregnant women. The findings demonstrated a dysregulation in copeptin and fibronectin serum levels between the normotensive pregnant and preeclamptic groups, suggesting a potential diagnostic indicator of PE development.
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