International Journal of Women's Health and Reproduction Sciences

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Jan 2021, Vol 9, Issue 1

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Original Article
The Association Between Platelets/Lymphocyte Ratio and Premature Rupture of Membranes
Seyedeh Hajar Sharami¹, Gelareh Biazar², Farnoush Farzi², Zahra Atrkarroushan³, Mohadese Ahmadi², Yasmin Chaibakhsh², Mohammad Reza Habibi², Mahsa Khosousi Sani¹, Nazanin Hoseinzade Sanatkar⁴
¹Reproductive Health Research Center, Department of Obstetrics and Gynecology, Al-Zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran ²Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran ³Department of Statistic, Guilan University of Medical Sciences, Rasht, Iran ⁴Student Research Committee, Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
IJWHR 2021; 9: 080-083 DOI: 10.15296/ijwhr.2021.14 Viewed : 1884 times Downloaded : 3475 times. Keywords : Premature rupture of membranes, Association, Platelet-to-lymphocyte ratio
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Abstract

Objectives: Premature rupture of membrane (PROM) refers to the spontaneous rupture of fetal membranes prior to delivery and the initiation of the labor. In addition, the early rupture of membranes can lead to several adverse complications for both the mother and the fetus. Therefore, the present study aimed to investigate the association between the platelet-to-lymphocyte ratio (PLR) and the premature rupture of the membrane in pregnant women. Materials and Methods: This retrospective case-control study reviewed the files of 150 women with PROM matched with 150 spontaneous preterm labor (SPL) women at Al-Zahra hospital of Rasht during 2017-2018. Demographic data, complete blood cell count, PLR, maternal age, gestational week, gravida, parity, and birth weight were recorded, and finally, the obtained data were analyzed by SPSS, version 19. Results: Based on the results, there was a statistically significant difference between maternal platelet count and PLR in these two groups (P = 0.0001). However, no significant difference was observed regarding maternal age, gravida, parity, and maternal lymphocytes count in PROM and control groups (P > 0.05). According to logistic regression analysis, a negative association was found respecting gestational age and PLR in the PROM group while a positive association was observed in the group without PROM regarding birth weight and PRL. In the receiver-operator curve diagram, the appropriate cut-off point for the PLR index for detecting PROM was determined as 142.2 with a sensitivity of 62.7% and a specificity of 63.3%. Conclusions: In general, a significant association was found between PLR and PROM. Therefore, well-planned cohort studies are welcomed to find any prognostic role for this marker.