|The Effects of Foeniculum vulgare Seed Extract on Fertility Results of Assisted Reproductive Technology in Women With Poor Ovarian Response|
|Mahnaz Yavangi1, Ilnaz Mohammadi2, Shahedeh Khansari3, Shirin Moradkhani4, Tayebe Artimani5, Saeid Heidari Soureshjani6|
|1Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2Department of Gynecology, Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3Department of Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Fatemieh Hospital, Hamadan, Iran
4Department of Pharmacognosy, School of Pharmacy, Medicinal Plants and Natural Product Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
5Department of Anatomy, Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
6Deputy of Research and Technology, Shahrekord University of Medical Sciences, Shahrekord
IJWHR 2020; 8: 203-208
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Keywords : Foeniculum vulgare, Fertility, Ovarian failure, Phytotherapy, Assisted reproductive techniques
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Objectives: Foeniculum vulgare due to phytoestrogens is important in the treatment of female sexual dysfunction including infertility. Accordingly, this study was conducted to investigate the effect of the F. vulgare seed extract on the fertility results of assisted reproductive technology (ART) in women with a poor ovarian response (POR).
Materials and Methods: In this before-after intervention, 19 infertile women with POR were enrolled by a convenience sampling method. The amounts of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), ovarian ultrasound volume, the number of preantral follicles, and the size of the prominent ovary were measured before treatment with F. vulgare. Then, patients were treated with F. vulgare for two months, followed by initiating the in vitro fertilization (IVF) cycle. The number of embryos transferred in previous and current cycles was investigated after IVF. Finally, the data were analyzed in SPSS 16.
Results: There was a significant difference in the serum LH level (P = 0.002), LH/FSH (P = 0.049), the number of follicles and ovules (P = 0.003), endometrial thickness (P = 0.04), and ovarian volume (P = 0.03) between before and after treatment with F. vulgare. Moreover, a significant difference regarding the decreased number of required days for induction was observed between before and after treatment with F. vulgare (P = 0.022).
Conclusions: In general, the use of F. vulgare had positive effects on improving the quality of oocytes and female fertility indices in women with POR.
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