Login Contact Us
Jan 2019, Vol 7, Issue 1
Advanced Search
How do you find the scientific quality of the published articles on our web site?

Original Article
The Ameliorative Effect of Galega officinalis Extract on Histological Damages, Oxidative Stress Induced by Torsion-Detorsion in Adult Rats' Ovarian
Farnaz Shokri1, Majid Shokoohi2, Ayda Roudi Rasht Abadi3, Hossein Kalarestaghi4
1Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Animal Biology, Faculty of Biology, University of Kharazmi, Tehran, Iran
4Department of Anatomy and Pathology, Research Laboratory for Embryology and Stem Cell, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

IJWHR 2019; 7: 119-123
DOI: 10.15296/ijwhr.2019.19
Viewed : 2516 times
Downloaded : 2531 times.

Keywords : Torsion-detorsion, Ovarian tissue, Galega officinalis, Oxidative stress markers, Steroidal hormones
Full Text(PDF) | Related Articles

Objectives: The antioxidative role of Galega officinalis extract has been reported in several studies. However, this experimental study was designed in order to investigate the impacts of G. officinalis extract against parameters, such as histological, hormonal, and oxidative stress parameters, which were induced by ovarian torsion/detorsion.

Materials and Methods: Adult female Wistar rats (n = 28) were randomly divided into 4 groups including sham (G1), ovarian torsion for 3 hours then-after detorsion (G2 or TD), ovarian torsion-detorsion orally received 50 mg/kg extract of G. officinalis (G3 or TDGO), healthy rats orally received 50 mg/kg hydroalcoholic extract of G. officinalis (G4 or GO). Ten days after torsion-detorsion, rats were sacrificed and their ovaries, and their blood levels of hormones including estrogen and testosterone, as well as some oxidative stress
markers were assayed.

Results: The structure of ovaries in TD groups of the study showed a notable change compared to other groups. The serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH), and also estrogen significantly decreased in TD group, while treatment with G. officinalis could prevent from decreasing mentioned parameters. Furthermore, although torsion-detorsion led to increasing the serum level of malondialdehyde (MDA), it was decreased after administration of G. officinalis.

Conclusions: Obtained results showed that G. officinalis could be useful in elevating the estrogen level, reducing the oxidative stress marker (i.e. MDA) and ovarian tissue damages induced by torsion-detorsion.

Cite By, Google Scholar

Google Scholar

Articles by Shokri F
Articles by Shokoohi M
Articles by Kalarestaghi H


Articles by Farnaz Shokri
Articles by Majid Shokoohi

Submit Paper
Online Submission System
IJWHR ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Published Article Statistics