International Journal of Women\'s Health and Reproduction Sciences

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Oct 2018, Vol 6, Issue 4

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Original Article
Correlation of Maternal KIR and Parental HLA-C Genes Diversity With Risk of Preeclampsia in Lorestan Province of Iran
Soheila Akbari¹, Seyyed Amir Yasin Ahmadi² , Farhad Shahsavar³ , Khatereh Anbari⁴
¹Department of Obstetrics and Gynecology, Lorestan University of Medical Sciences, Khorramabad, Iran ²Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran ³Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran ⁴Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
IJWHR 2018; 6: 452?458 DOI: 10.15296/ijwhr.2018.75 Viewed : 3733 times Downloaded : 3879 times. Keywords : HLA-C, KIR, NK cells, Preeclampsia
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Abstract

Objectives: Fetomaternal immune tolerance induced by natural killer cells (NKs) is a necessary phenomenon associated with maternal killer-cell immunoglobulin-like receptors (KIRs) and fetal human leukocyte antigens (HLAs). We aimed to investigate maternal KIR, parental HLA-C, and maternal-parental KIR-HLA combination in 2 preeclampsia and control groups. Materials and Methods: A total of 200 couples participated in this case-control study. DNA samples were assayed through polymerase chain reaction with sequence specific primers (PCR-SSP). Results: No significant difference was observed between the cases and the controls regarding the maternal KIR genes and genotypes and paternal HLA-C genes. A significant relation was found for maternal KIR and paternal HLA-C combination. The relation was for the inhibitory combination KIR2DL1+HLA-C2 in the preeclampsia group (P < 0.05; odds ratio [OR] = 2.02; sensitivity = 79%). In addition, maternal AA genotype of KIR in combination with paternal HLA-C1C2 was a risk factor (P < 00.05; OR = 3.24; specificity = 92%). Conclusions: The inhibitory maternal-paternal combinations KIR2DL1+HLA-C2 and AA+HLA-C1C2 seem to be more associated with risk of preeclampsia. Prediction of the risk of preeclampsia with the help of maternal KIR typing and paternal HLA-C typing can be possible in future.