International Journal of Women's Health and Reproduction Sciences

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Apr 2017, Vol 5, Issue 2

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Original Article
Uterine and Serum Glycodelin Concentration in Recurrent Implantation Failure Versus Normal Fertile Women on Implantation Window
Robabeh Taheripanah¹, Marzieh Zamaniyan², Shahrzad Akhoondzadeh¹, Anahita Taheripanah³, Narges Malih⁴
¹Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran ²Infertility center, Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran ³Department of Molecular and Cellular Sciences, Faculty of Advanced Sciences and Technology Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran ⁴4Department of Health and Community Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
IJWHR 2017; 5: 103-106 DOI: 10.15296/ijwhr.2017.19 Viewed : 4608 times Downloaded : 4276 times. Keywords : Embryo implantation, Endometrium, Fertilization in vitro, Glycodelin, Infertility
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Abstract

Objectives: Glycodelin is a factor which regulates immunological activity and is required in implantation window. The present study was conducted to compare glycodelin concentrations in blood and uterine flushing samples from women with in vitro fertilization (IVF) failure and fertile controls. Materials and Methods: This was a prospective clinical trial including 20 women with IVF failure and 19 fertile participants. Both groups initially filled a special questionnaire including their demographic profile and prior failed IVF attempts. Then samples of uterine flushing and blood samples were taken to measure glycodelin concentrations. Results: There were significant differences between mean glycodelin concentrations in the case and control groups, both in serum glycodelin (30.1 ± 5.30 vs. 44.5 ± 11.85 ng/mL, P < 0.001), and uterine flushing glycodelin concentrations (310.0 ± 67.51 vs. 498.3 ± 119.01 ng/mL, P < 0.001). The mean total glycodelin concentration in uterine flushing was higher than serum in both groups (399.4 ± 133.95 vs. 36.9 ± 1.52 ng/mL, P < 0.001). Conclusion: We found a significant decrease in glycodelin concentrations among patients with IVF failure. Since glycodelin has a role in immune system during endometrial receptivity, therefore, it may be required for prevention of IVF failures.