Materials and Methods: In a randomized, controlled clinical trial, 141 women 20-35 years selected for IUI among patients referring to infertility clinic of Al-Zahra hospital in Tabriz, Iran in 2013.they were entered into study in two groups of simultaneous (n= 71) and standard (n = 70). After ovulation stimulation by clomiphene and human menopausal gonadotropin (HMG) and creating up to 3 dominant follicles in each patient, a single dose of HCG was administered; thereafter, IUI was done in the simultaneous group instantly and 34-40 hours following HCG injection in the standard group.

Results: In the standard and simultaneous groups, mean pregnancy rate per patient was 25.7% and 21.1% respectively (p= 0.52) and pregnancy rate per IUI cycle was 16.4% and 15.3% respectively (p= 0.82) that was not significantly different. Furthermore, between two groups in terms of age, the number of mature follicles, and endometrial thickness, there was no significant difference.

Conclusion: Although difference in pregnancy rate between two groups was not statistically significant, simultaneous HCG with IUI is a comfort method for patients due to less cost and fewer patient's referrals to clinic.