|False-Positive Results in Pregnancy Screening for Aneuploidy|
|Farnaz Sahhaf1, Arezoo Alimohammadi1, Sanaz Mosavi2|
|1Alzahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
2Taleghani Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
IJWHR 2020; 8: 418-422
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Keywords : Screening, Down syndrome, Maternal outcomes, Neonatal outcomes
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Objectives: The screening of chromosomal aberrations is one of the most common methods during pregnancy although this test is occasionally false-positive.
Materials and Methods: In this case-control study, 252 mothers with false-positive (n=126) and -negative (n=126) tests were evaluated respectively. Demographic data during pregnancy and postpartum included maternal and neonatal complications, and finally, perinatal variables were compared between the two groups.
Results: The mean age of the case group was significantly higher than that of the control group (P < 0.001). In addition, lower smoking history in the spouse (P = 0.01), higher prevalence of preeclampsia (P = 0.33) and proteinuria (P = 0.03), preterm infant (P = 0.01), and low birth weight (P = 0.04) were observed in this group as well. Eventually, the shorter height P = 0.004) and lower 5-minute Apgar score (P = 0.03) were found in infants.
Conclusions: In general, mothers with positive screening results showed a higher risk of preeclampsia and preterm labor in comparison with those with false-negative screening results.
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