|Demographic, Anthropometric, and Biochemical Characteristics ofJordanian Women with Polycystic Ovary Syndrome :A Case–control Study|
|Jehan Hamadneh1, Nahla S. Al-bayyari2, Shereen Hamadneh3, Safaa Al-Zeidaneen4, Hadil Subih2, Samar Z. Burgan5, Zouhair O. Amarin1|
|1Department of Obstetrics and Gynaecology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
2Department of Nutrition and Food Technology, Al-Huson University College, Al-Balqa Applied University, Irbid, Jordan
3Department of Maternal and Child Health, Faculty of Nursing, Al-albayt University, Mafraq, Jordan
4Department of Allied Medical Sciences, Faculty of Al-Zarqa University College, Al-Balqa Applied University, Al-Salt, Jordan
5Department of Oral and Maxillofacial Surgery, Oral Medicine and Periodontology, School of Dentistry, The University of Jordan, Amman, Jordan
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Keywords : Polycystic Ovary Syndrome, Homocysteine, Androgens, Lipids
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Objectives: To compare the demographic, anthropometric, and biochemical characteristics between healthy women and women with polycystic ovary syndrome (PCOS),to identify independent biochemical markers of PCOS.
Materials and Methods: A case–control study of 77 women with PCOS and 73 healthy controls aged between 18 and 49 years. Blood samples were obtained for the determination of plasma total homocysteine, total cholesterol, triglycerides, low- and high-density lipoprotein, total cholesterol/high-density lipoprotein ratio, total testosterone, sex hormone-binding globulin, and free androgen index. Multivariable logistic regression analysis was performed to identify independent biochemical markers of PCOS.
Results: The mean differences between cases and controls in plasma total homocysteine, triglycerides, and sex hormone-binding globulin were statistically significant. Plasma total homocysteine and triglycerides were elevated in cases, while sex hormone-binding globulin was reduced. All three markers were identified as independent predictors of PCOS in multivariable analysis, in addition to a fourth, total testosterone. Plasma total homocysteine is an independent biomarker of PCOS despite a relationship with triglycerides and total cholesterol, the former of which is itself an independent biomarker.
Conclusions: Overweight women with PCOS have higher levels of plasma total homocysteine and triglycerides and a lower level of sex hormone-binding globulin compared with healthy controls. The level of plasma total homocysteine is a marker of PCOS independent of the lipid profile. The differential biochemical profile of women with PCOS and healthy women provides useful hint for the diagnosis of PCOS and must be addressed in relation to the risk of cardiovascular disease.
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