|The Effect of Nimodipine on Premature LH Surge in Women Undergoing Intra Uterine Insemination|
|Zahra Razghandi1, Robabeh Taheripanah1, Zahra Heidar1|
|1Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran|
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Keywords : Nimodipine, LH surge, intra uterine insemination, GnRH agonist, GnRH antagonist, calcium channel blocker, Iran
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Objectives: To determine the effect of Nimodipineon on premature LH surge in women undergoing intrauterine insemination (IUI).
Materials and Methods: Fifty six infertile women referred to Mahdiyeh hospital, Tehran, Iran,who underwent IUI treatment in year 2017 participated in this randomized clinical trial.Participants were randomly divided into Nimodipine (N=34) and placebo (N=22) groups.Demographic and clinical profile of women were collected using a predesignated checklist. In the Nimodipine group, 30mg tablets were given to patients three times daily for two days. The serum levels of LH and estradiol were measured before and after intervention.
Results: In 29 (78.4%) woman LH surge was not seen in Nimodipine group whil LH surge was seen in 8 (34.8%) women in placebo group (P=0.04). There were no statistically differences in serum levels of estradiol and LH between two groups before intervention. The serum levels of estradiol in both groups increased after intervention, however this increase was not significant. There was no statistically difference between two groups in terms of fertility rate.
Conclusion: Nimodipine can significantly reduce premature LH surge in patients undergoing IUI compared to placebo.
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