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Oct 2019, Vol 7, Issue 4
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Original Article
An Investigation Into the Effects of Magnesium Sulfate on the Complications of Succinylcholine Administration in Nulliparous Women Undergoing Elective Cesarean Section: A Double-Blind Clinical Trial
Davoud Aghamohamadi1, Mehdi Khanbabayi Gol2
1Nursing Research Committee of Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Anesthesiology, School of Medicine, Imam Reza Medical, Research & Training Hospital, Tabriz University of Medical Sciences

IJWHR 2019; 7: 520-525
DOI: 10.15296/ijwhr.2019.86
Viewed : 197 times
Downloaded : 123 times.

Keywords : Succinylcholine, Fasciculation, Magnesium sulfate
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Abstract
Objectives: Controlling the complications of anesthetics (e.g., succinylcholine) seems necessary since they are greater for nulliparous women who undergo elective cesarean section (C-section). The present study aimed to investigate the effects of magnesium sulfate on the complications of succinylcholine administration in nulliparous women undergoing elective C-section.

Materials and Methods: This double-blind clinical trial was conducted on 60 nulliparous women during 2012-2013. The women were randomly assigned to A and B groups. Before inducing the rapid anesthesia with succinylcholine, patients in the intervention group received 30 mg/kg of magnesium sulfate within 10 minutes and then the hemodynamic status and the side effects of succinylcholine were recorded in a special form. Statistical tests were performed using repeated-measures ANOVA, chi-square test, and one-way ANOVA tests and the level of significance was determined to be P < 0.05.

Results: There was no significant difference between the two groups in terms of demographic data (P > 0.059). However, the results indicated that there was a significant difference between the 2 groups regarding the myoglobin level (P = 0.010). Contrarily, the results showed that most patients in the intervention (n=23) and control (n=15) groups experienced no or mild and severe fasciculation, respectively (P < 0.001).

Conclusions: In general, magnesium sulfate can greatly control and reduce the complications of succinylcholine administration, including fasciculation.

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