|Trichorionic Triamniotic Triplets After Single Embryo Transfer: A case Series and Literature Review|
|Isao Takehara1, Toshifumi Takahashi2, Kuniaki Ota2, Nobuhiko Ohta3, Hideki Mizunuma2, Satoru Nagase1|
|1Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata , Japan
2Fukushima Medical Center for Children and Women, Fukushima Medical University, Fukushima, Japan
3Yume Clinic, Yonezawa, Japan
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Keywords : Triplets, Assisted Reproductive Technology, Monozygotic Triplet, Single embryo transfer
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Objectives: Monozygotic triplet pregnancy very rarely occurs in assisted reproductive technology treatment. We report two cases of trichorionic triplet pregnancies after single embryo transfer (SET) and review the literature.
Case presentation: In the first case, a 29-year-old female underwent the long protocol using gonadotropin-releasing hormone analogue, and one full blastocyst was transferred in a fresh cycle. At 6 gestational weeks, three gestational sacs were clearly observed, and after 1 week, only one fetus with fetal heart beat was found. In the second case, a 39-year-old female underwent intracytoplasmic sperm injection treatment, and seven embryos were frozen. After assisted hatching, one fully expanded blastocyst was transferred during a hormone replacement cycle. At 6 gestational weeks, three gestational sacs with three yolk sacs were observed. After 1 week, two fetuses with fetal heart beat were found.
Conclusion: Although the developmental mechanisms of monozygotic triplets are unknown, clinicians should be aware of the possibility of multiple pregnancies under SET.
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