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Apr 2019, Vol 7, Issue 2
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Original Article
Glycated Hemoglobin and Lipid Profile Association Among Pregnant Women in Saudi Arabian Population
Farah Anjum Rana Zaini1, 2, Ashjan Shami1, Amani Rehaili1, Rahma Kufia3
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia
2College of Community Service and Continuing Learning, Taif University, Taif, Saudi Arabia
3Ministry of Health, Mecca, Kingdom of Saudi Arabia


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Keywords : Gestational diabetes mellitus, lipid profile, Glycated hemoglobin
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Abstract

Objectives: Glycated hemoglobin (HbA1c) is the most commonly used glycemic index among diabetic patients. We seek to find out the relationship between HbA1c and lipid parameters among healthy pregnancies and gestational diabetic cases.

Materials and Methods: Seventy five pregnant Saudi women in the age group nineteen years to forty three years, were selected for this cross-sectional study. The participants were categorized into two groups; with and without GDM, had no previous history of chronic illnesses, were all non-smokers and not on any medications that could alter lipid profile and HbA1c concentrations. 75 gram oral glucose tolerance test (OGTT) was utilized to identify twenty five women with GDM. All biochemical tests including HbA1c, fasting blood sugar (FBG), total cholesterol (TC), low-density lipoprotein (LDL-cholesterol), triglycerides (TG) and high-density lipoprotein (HDL-cholesterol) were done with the help of biochemical auto-analyzer. Collected data were analyzed statistically using paired student’s t-test. P-values of <0.05 were considered statistically significant on all analysis of healthy pregnancies and those with GDM.

Results: The HbA1c and FBG values showed significant correlation with GDM (p<0.001each). TC, LDL-cholesterol and TG did not show any significant difference between the two groups. However, HDL-cholesterol and ratio of TG and HDL-cholesterol revealed remarkable difference between GDM and healthy subjects (p-value < 0.05 each).

Conclusion: Blood levels of glucose, HbA1c, TG and HDL-cholesterol are of paramount significance in gestational diabetes mellitus. We predict that HbA1c can be used as one of the markers in evaluation of risk factors in the development of dyslipidemia among pregnant women.

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