|Investigation the Role of Hydroalchoholic extract of Apium Graveolens and Cinnamon Zeylanicum on Metabolically Change and Ovarian Oxidative Injury in a Rat Model of PCOS|
|Fariba Khodaeifar1, Seyyed Mohammad Bagher Fazljou1, Arash Khaki2, Mohammad Ali Torbati3, Elahe Olad Saheb Madarek 2, Amir Afshin Khaki4, Majid Shokoohi4,5, Amir Hossein Dalili6|
|1Department of Traditional Medicine, Faculty of Traditional med, Tabriz University of Medical Sciences, Tabriz, Iran
2Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Food Science and Technology,Faculty of Nutrition ,Tabriz University of Medical Sciences, Tabriz ,Iran
4Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
6Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords : Apium graveolens, Cinnamon Zeylanicum, PCOS, Lipid profile
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Objectives: The aim of the present research was to Compression the Role of hydroalchoholic extract of Apium Graveolens and Cinnamon Zeylanicum on metabolically change and ovarian oxidative injury in a rat model of polycystic ovary syndrome.
Materials and Methods: In our research, experimentally, 64 female rats with Wistar Breed were used (n=8/group) including G1: healthy control, G2: PCOS which were received no therapy, G3: PCOS + Apium graveolens, G4: Apium graveolens. G5: PCOS + Cinnamon Zeylanicum, G6: no PCOS + Cinnamon Zeylanicum, G7: PCOS + C. Zeylanicum and A. graveolens, G8: Cinnamon Zeylanicum and Apium graveolens. Induction of PCOS was carried out by a single dose of "estradiol valerate" intramuscular injected(16mg/kg). After 14 days, animals anesthetized, then their plasma samples for checking the blood sugar (BS), insulin, and lipid profile were used . The ovarian of rats were removed and fixed for histopathological assessment, as well as oxidative stress marker in ovarian tissue were assessed.
Results: The levels of BS, insulin, and lipid profile in plasma enhanced in G2, significantly (P<0.05), while they were diminished in therapy groups, significantly (P<0.05). Moreover, the serum level of HDL was declined in G2, significantly (P<0.05), while in therapeutic animals, they were enhanced, significantly (P<0.05). moreover, in the ovarian tissue observed a negative change in PCOS group, as well as the oxidative stress enhanced in ovarian tissue. while in the treated groups improved this change.
Conclusion: It beseems the extract of Apium graveolens and Cinnamon Zeylanicum has a useful impact on regulating of serum levels of FBS, insulin, lipid profile and oxidative stress markers in the palliation of PCOS complications.
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