|The Serum Level of Vitamin D in Women With Urinary Incontinence Due to Pelvic Floor Disorder and Prolapse: A Regional Case-Control Study on Iranian Population|
|Shahnaz Barat1, Zinatossadat Bouzari2, Shabnam Mehdinia3, Karimollah Hajian-Tilaki4, Mojgan Naeimi Rad5|
|1Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R. Iran
2Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R. Iran
3Committee of Research, Babol University of Medical Sciences, Babol, Iran
4Department of Biostatics and Epidemiology, Non-Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran
5Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, I.R. Iran
IJWHR 2019; 7: 067-073
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Keywords : Pelvic floor disorders, Vitamin D, UI, Women
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Objectives: Vitamin D is important for the muscular tone and bone metabolism. Due to the high prevalence of vitamin D deficiency in Iranian women, this study aimed to investigate the difference in vitamin D levels between patients with and without pelvic floor disorder (PFD) to assess the possible effect of vitamin D on PFD.
Materials and Methods: The present case-control study examined 209 women referring to Ayatollah Rouhani hospital of Babol in 2017. Patients were explored for prolapse and those with at least one disorder or without PFD were categorized as the case (n = 104) or control (n = 105) groups, respectively. Then, the serum level of 25-hydroxy vitamin D was compared between the groups.
Results: The mean age and abdominal circumference of the patients were significantly higher in the case group (P < 0.001 & P = 0.046, respectively) as compared to the control group. Meanwhile, the total mean ± SD serum level of vitamin D was 20.03±17.88 ng/mL and significantly higher in the case group (24.58 ± 20.75 ng/mL) than that of the control group (15.53±13.11 ng/mL), especially in patients with stress and urgency urinary incontinence (SIU/UIU) (both with a significance level of P < 0.001).
Conclusions: As a result of PFD, the group with UI, especially the one with SIU or UIU had the highest vitamin D level compared to the control and other groups. Nonetheless, the mean age and educational level were significantly higher and lower in this group, respectively. These results could be due to the multifactorial nature of vitamin D level, that is, it varies based on nutrition, place of residence, and other factors.
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