|Hyoscine Butylbromide and the Duration of Labor: A Systematic Review and Meta-analysis Study|
|Mehdi Ranjbaran1, Reza Omani Samani2, Maryam Hafezi3, Kamyar Mansori4,5, Nader Mahdavi6, Hebteyes Hailu Tola7|
|1Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
2Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, ACECR, Royan Institute, Tehran, Iran
3Department of Endocrinology and female Infertility, Reproductive Biomedicine Research Center, Royan institute for Reproductive Biomedicine, ACECR, Tehran, Iran
4School of Public Health, Dezful University of Medical Sciences, Dezful, Iran
5Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
6Department of Epidemiology, Faculty of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7Department of Epidemiology and Biostatistics, International Campus, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
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Keywords : Hyoscine-N-butylbromide, Labor, Obstetric, Labor Onset
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Objectives: Hyoscine Butylbromide is among the drugs that used to shorten prolonged labor. It helps in decreasing the complications and pain related to prolonged labor. To prescribe this drug, understanding of its effect on the duration of labor is important through summarizing the available primary study results.. Therefore, we aimed to determine the effect of Hyoscine Butylbromide in shortening the duration of labor through summarizing the available primary evidence.
Materials and Methods: We searched electronic databases including International Scientific Indexing Web of Science, PubMed/Medline and Scopus for published articles in English language between 2000 and 22 August 2017. We analyzed the data by Stata ver.11 software. The effect of Hyoscine Butylbromide was estimated by Mean Difference (MD) and Confidence Interval (CI) as summary measures using random-effects meta-analysis model.
Results: Hyoscine Butylbromide was significantly reduced the duration of labor in intervention group when compared to placebo group in the first (MD = -67.77 minutes, CI 95%; -90.98 to -44.56), and second stage of labor (MD=-2.76 minutes, CI 95%; -4.79 to -0.74). However, it was not significantly reduced the duration of labor in third stage (MD = -0.45 minutes, CI 95%; -1.45 to 0.56) in intervention group.
Conclusion: In this review, Hyoscine Butylbromide was significantly reduced the duration of labor in first and second stages. However, it was not significantly reduced the duration in the third stage. Thus, Hyoscine could be used for the reduction of labor duration in first and second stages of labor.
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