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Jan 2019, Vol 7, Issue 1
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Original Article
Comparison of Hemodynamic Changes Due to Endotracheal Intubation with Labetalol and Remifentanil in Severe Preeclamptic Patients Undergoing Cesarean Delivery with General Anesthesia
Sousan Rasooli1, Farnaz Moslemi1, Hale Vazifehshenas1, Reyhaneh Abri1, Majid Shokoohi3
1Department of Anesthesiology ,Tabriz University of Medical Sciences, Women’s Reproductive Health Research Center, Tabriz, Iran
2Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran


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Keywords : Labetalol, Remifentanil, Stress responses, Intubation, Preeclampsia
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Abstract

Objectives:Stresses responses to laryngoscopy and intubation are exaggerated in the patient with severe preeclampsia and this stress can lead to increased risk of maternal mortality and morbidity. The aim of this study was to compare the efficacies of Remifentanil and Labetalol in attenuating these responses in women with severe preeclampsia undergoing cesarean section with general anesthesia.

Patients and Methods:In this double-blind study, 70 women with severe preeclampsia undergoing cesarean delivery were randomly assigned in two groups to receive either Remifentanil 1 µg/kg or Labetalol 0.25 mg/kg before induction of anesthesia. Blood pressure and Heart Rate were measured before and 1, 3, 5 minutes after intubation. Neonate’s the and 5th minute Apgar scores were evaluated.

Results:All hemodynamic variables decreased in both groups after administration of Remifentanil or Labetalol. Compare to Remifentanil, Labetalol significantly attenuated the rise in blood pressure and heart rate during laryngoscopy and intubation (P<0/001). No significant difference was found between neonates apgar scores of two groups (P=0.97, P=0.19 respectively).

Conclusion:Administration of Labetalol before induction of anesthesia can control stress responses to laryngoscopy and intubation better and more stable than Remifentanil in patients with severe preeclampsia undergoing the cesarean section.

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