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May 2014, Vol 2, Issue 3
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Original Article
Ultra-structural Study by Transmission Electron Microscopy: Effect of Omega-3 on Ovary Cell Organelles after Experimental Induced Poly Cystic Ovary Syndrome
Elahe Ouladsahebmadarek1, Arash Khaki2
1Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran

IJWHR 2014; 2: 186-194
DOI: 10.15296/ijwhr.2014.27
Viewed : 1398 times
Downloaded : 1884 times.

Keywords : Estradiol-Valerate, Omega-3, Ovary, PCO
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Abstract
Objectives: Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility, affecting about 4% to 8% of women in the age of procreation. For evaluation the protective effects of omega-3 polyunsaturated fatty acid on ovarian structure in experimental PCO induced by estradiol-valerat, this research was done.

Materials and Methods: Wistar female rats (n=40) were allocated into four groups, one control (n=10) and three test groups (n=30), that one group received omega-3 (60 mg/rat/orally/daily), second and third groups were induced PCO by single injection of estradiol-valerate (16mg/ kg/ i.m), third group also received omega-3 (240 mg/kg) for 60 consequence days. Animals were kept in standard conditions. On day 60, the ovarian tissue of Rats in whole groups were removed and prepared for pathological analysis.

Results: vacuolated area and rough endoplasmic reticulum expanded, de-granulated, disorganized were seen in PCO groups; however, these side effects decreased in the groups that received omega-3 significantly (p<0.05) in comparison to experiment groups and ovarian weights in PCO experimental decreased significantly (p<0.05).

Conclusion: Results revealed that administration of omega-3 could significantly treat PCO. This suggested that polyunsaturated fatty acid could diminish negative side effects of PCO on ovary tissue.

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