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Oct 2018, Vol 6, Issue 4
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Original Article
Prophylactic Effect of Tranexamic Acid on Hemorrhage during and After the Cesarean Section
ForozanMilani1, Katayoun Haryalchi2, Seyedeh Hajar Sharami1, Zahra Atrkarroshan3, Sara Farzadi1
1Department of Obstetric and Gynecology, Reproductive ,Health Research Center, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2Department of Anesthesiology, , Reproductive Health Research Center, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3Department of Biostatistics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran


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Keywords : Tranexamic acid, bleeding, caesarian secession
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Abstract

Objectives: Recent guideline from the World Health Organization indicated administering Tranexamic Acid for treatment of Post-partumhemorrhage, it is crucial to find low-cost and low-risk alternative methods for controlling obstetric hemorrhage. We aimed to evaluate Prophylactic Effect of Tranexamic Acid on Hemorrhage during and After the Cesarean Section

Materials and methods: This randomized double blind control trial has been performed on 60 women who underwent cesareansection with spinal anesthesia. participants were randomly assigned into 2  groups.  Experimental groupreceived one gram Tranexamic acid 15 minutes before the incision and control group received dextrosewater 5 % as a placebo. The amount of bleeding was measured during and after surgery. Data were entered in SPSS version 21 and reported by descriptive statistics and analyzed using Chi-square, T-test, Mann Whitney U test, Paired T-test,ANCOVA and Wilcoxon test.

Results: Results showed that 60 patients were participated. Results showed  no significant difference regarding mean age, mean gestational age and the Prothrombin time  and Partial thromboplastin timebetween groups (P>0.05). The mean total bleeding volume in Experimental and control groups were551.8  and  713.1 ml,  respectively  and  significant  difference  was  noted  (P=0.006).  No  significantdifference  was  noted  regarding  changes in hemoglobin concentration, systolic and diastolic bloodpressure and heart rate in groups.

Conclusions: According to results, administering 1 mg Tranexamic acid in cesarean section reduced the volume ofpostpartum hemorrhage significantly and it did not cause significant changes on hemodynamic state orhemoglobin level. Therefore, it seems that it can be recommended as an appropriate treatment for thesepatients.

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