|Prophylactic Effect of Tranexamic Acid on Hemorrhage during and After the Cesarean Section|
|ForozanMilani1, Katayoun Haryalchi2, Seyedeh Hajar Sharami1, Zahra Atrkarroshan3, Sara Farzadi1|
|1Department of Obstetric and Gynecology, Reproductive ,Health Research Center, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2Department of Anesthesiology, , Reproductive Health Research Center, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3Department of Biostatistics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
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Keywords : Tranexamic acid, bleeding, caesarian secession
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Objectives: Recent guideline from the World Health Organization indicated administering Tranexamic Acid for treatment of Post-partumhemorrhage, it is crucial to find low-cost and low-risk alternative methods for controlling obstetric hemorrhage. We aimed to evaluate Prophylactic Effect of Tranexamic Acid on Hemorrhage during and After the Cesarean Section
Materials and methods: This randomized double blind control trial has been performed on 60 women who underwent cesareansection with spinal anesthesia. participants were randomly assigned into 2 groups. Experimental groupreceived one gram Tranexamic acid 15 minutes before the incision and control group received dextrosewater 5 % as a placebo. The amount of bleeding was measured during and after surgery. Data were entered in SPSS version 21 and reported by descriptive statistics and analyzed using Chi-square, T-test, Mann Whitney U test, Paired T-test,ANCOVA and Wilcoxon test.
Results: Results showed that 60 patients were participated. Results showed no significant difference regarding mean age, mean gestational age and the Prothrombin time and Partial thromboplastin timebetween groups (P>0.05). The mean total bleeding volume in Experimental and control groups were551.8 and 713.1 ml, respectively and significant difference was noted (P=0.006). No significantdifference was noted regarding changes in hemoglobin concentration, systolic and diastolic bloodpressure and heart rate in groups.
Conclusions: According to results, administering 1 mg Tranexamic acid in cesarean section reduced the volume ofpostpartum hemorrhage significantly and it did not cause significant changes on hemodynamic state orhemoglobin level. Therefore, it seems that it can be recommended as an appropriate treatment for thesepatients.
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