|Evaluation of Plasma D-Dimer Concentration among Normal and Complicated Pregnancies, Saudi Arabia|
|Rana Zaini1, Amani Al-Rehaili2, Rahma Kufia3|
|1Taif University, Deanship of Community Service and Sustainable Development , Taif, Kingdom of Saudi Arabia
2Taif University, Clinical Laboratory Department, College of Applied Medical Sciences, Taif, Kingdom of Saudi Arabia
3Ministry of Health, Makkah, Kingdom of Saudi Arabia
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Keywords : D-dimer; Pregnant, Complicated,Gestational diabetes, Hypertension, Saudi Arabia
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Objective: The purpose of current work isto evaluate the D-dimer plasma level among both normal and complicated pregnancies such as gestational diabetes (GD) and hypertension (GH) among Saudi female. It is also focused on exhibiting any possible factors that could also play a role in rising D-dimer levels besides the age of the pregnant woman and the period of gestation.
Materials and Methods: A semi-quantitative latex agglutination assay was performed in blood sample of healthy non-pregnant, pregnant and pregnant females with complicated pregnancy such as GD and GH.
Results: The results exhibitedthat 92% of pregnancies with GH and 90% of multiple pregnancies had high D-dimer levels. The analysis of the effect of age of pregnant women on D-dimer concentrations presented that 100% of pregnant women with GD, GH or had multiple pregnancies were aged above forty, had high levels of D-dimer. The results of gestational age of pregnancies with D-dimer showed that by reaching the third trimester, about 66.6 % of women who had multiple pregnancies had D-dimer concentration levels above 2,000 ng/mL. Interestingly, all the pregnant females with GH had D-dimer concentrations above 2,000 ng/mL.
Conclusion:This study postulated that the concentrations of D-dimer significantly increase during pregnancy associated with common complications such as GD and GH. It is first to demonstrate the possible risk factors during pregnancy-included age, number of pregnancies, gestational age and pregnancies with GD and GH, especially among Saudi Arabian women.
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