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Apr 2019, Vol 7, Issue 2
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Original Article
Comparison of Pregnancy Rate in Patients With Polycystic Ovary Syndrome Treated With Clomiphene Alone and In Combination With N-acetyl Cysteine: A Randomized Clinical Trial
Nayereh Ghomian1, Nayereh Khadem1, Somayeh Moeindarbari1, Aghdas Abdolrazagh1
1Department of Obstetrics and Gynecology, Neonatal and Maternal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

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Keywords : Clomiphene citrate, Endometrium, N-acetylcysteine, Polycystic ovary syndrome, infertility
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Objectives: Polycystic ovary syndrome (PCOS) is one of the frequent endocrine disorders among the young females, which can cause infertility. Recently, evidence has shown the beneficial impacts of N-acetyl cysteine (NAC) use along with clomiphene citrate on the treatment of infertility caused by PCOS. Regarding this, the present study aimed to compare the pregnancy rate between the PCOS patients treated with clomiphene and those received clomiphene along with NAC.

Materials and Methods: This blinded randomized controlled clinical trial was performed on the 66 patients with PCOS who presented with infertility at the Milad Infertility Center in Mashhad, Iran, in 2015. The patients were divided into two groups of intervention and control using the random number table. In the intervention group, 100 mg clomiphene (i.e., two pills) along with 1200 mg NAC (i.e., two 600 mg pills) were given to the participants from the third day of the menstrual cycle for five days. In the control group, 100 mg clomiphene was administered from the third day of the cycle for five days. The patients' response to medications as well as the number and size of follicles were assessed using the vaginal ultrasound.

Results: The two study groups had no significant difference regarding age, duration of infertility, body mass index, history of infertility treatment, and endometrial thickness on the third day of the menstrual cycle. The mean endometrial thickness was 7.47±1.6(NAC/clomiphene) and 7.58±2.1 mm(clomiphene) on the 12th day of the menstrual cycle(P=0.810). Furthermore, the mean sizes of the follicles were 13.6±4.2(clomiphene) and 15.9±5.1 mm(NAC/clomiphene)(P=0.301). The mean numbers of follicles were 1.56±0.9(clomiphene) and 1.8±0.9(NAC/clomiphene)(P=0.069). In total, seven (21.2%) and five (15.1%) patients in the intervention and control groups have a positive beta-hCG response, respectively (P=0.260).

Conclusion: As the findings of this study revealed, the addition of NAC to clomiphene treatment was not associated with an increased chance of pregnancy in the patients with PCOS-related infertility.

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