Login Contact Us
Jan 2019, Vol 7, Issue 1
Advanced Search
Title
Authors
Keyword
Poll
How do you find the scientific quality of the published articles on our web site?
Original Article
An Evaluation Of The Use Of Granulocyte Colony Stimulating Factor As An Adjunct To In Vitro Fertilization In Women Who Have Previously Failed Attempts At Pregnancy With In Vitro Fertilization
Tasneem Mohamed1, Mohamed Iqbal Cassim2, Yasmin Adam1
1Department of Obstetrics and Gynaecology,WITS,Johannesburg, South Africa
2Bio ART Fertility Centre , Gynaecology and Infertility, Johannesburg, South Africa


Viewed : 266 times
Downloaded : times.

Keywords : G-CSF, IVF, Endometrium, Pregnancy
| Related Articles
Abstract
Objectives: To evaluate the effects of Granulocyte Colony Stimulating Factor (G-CSF) as an adjunct to Invitro fertilization (IVF). The study looked at the influence of G-CSF on the endometrium and on the achievement of pregnancy.

Materials and Methods: A retrospective cross-sectional study of a subgroup of women attending a fertility clinic in Johannesburg, who had two or more failed IVFs previously. These women underwent a procedure of transvaginal infusion of G-CSF in addition to their IVF protocol. Endometrial thickness was not a criterion for its use.

Results: The group consisted of 49 women, mean age 38.9 years (SD ± 6.11). The mean number of previous IVFs was 3.1 (SD ± 1.76). Mean endometrial thickness pre-GCSF was 7.53mm (SD ± 2.69) and post-GCSF was 9.11mm (SD ± 2.12). The clinical pregnancy rate was 34.69%. Univariate analysis between those that achieved pregnancy and those that didn’t showed that the age difference between the two groups was significant statistically (p=0.0005). G-CSF use was associated with increased pregnancy rates in younger women. Mean endometrial thickness pre and post-GCSF between the two groups was not significant statistically (p>0.05). However the mean change in endometrial thickness in all women regardless of pregnancy outcome was statistically significant (p= 0.0029).

Conclusion: G-CSF is a useful adjunct in the treatment of women aged less than 38 years with recurrent failed IVFs. We reported a statistically significant overall expansion of endometrial thickness with the use of G-CSF but failed to show any association between endometrial expansion and pregnancy outcome.

Cite By, Google Scholar

Google Scholar

Articles by Mohamed T
Articles by Iqbal Cassim M
Articles by Adam Y

PubMed

Articles by Tasneem Mohamed
Articles by Yasmin Adam

Submit Paper
Online Submission System
IJWHR ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Published Article Statistics