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Apr 2020, Vol 8, Issue 2
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Original Article
The Effect of Psyllium (soluble fiber) Supplementation on Insulin Resistance and Lipid Profile in Non-Diabetic Women with Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Trial
Fatemeh Pourbehi1, Parvin Ayremlou2, Alireza Mehdizadeh3, Rasoul Zarrin4
1Department of Nutrition, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
2Clinical Research Development Unit of Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran
3Department of Internal diseases, Urmia University of Medical Sciences, Urmia, Iran
4Department of Nutrition, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

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Keywords : Psyllium, Polycystic ovary syndrome, Insulin resistance, Lipid Profile, clinical trial
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Objectives: Polycystic ovary syndrome (PCOs) is the most common cause of infertility in women. The risk of type-2 diabetes mellitus (T2DM), hyperinsulinemia and insulin resistance is higher among women with PCOs. Psyllium can reduce the levels of fasting blood glucose (FBS), insulin resistance and the lipid profile. We aimed to evaluate the effect of psyllium supplementation on insulin resistance and the lipid profile in non-diabetic women with PCOs.

Materials and Methods: A randomized double blind placebo-controlled trial. 54 eligible non-diabetic women with PCOs aged 18-45 recruited from an endocrinology clinic were divided into two groups based on their BMI through Stratified-Block Randomization. Participants in the intervention and placebo groups received 5g of psyllium or cellulose microcrystalline twice a day for 8 weeks. Fasting insulin, FBS, insulin resistance indicators including HOMA1-IR, HOMA2-IR, and QUICKI and the lipid profile were evaluated before and after the intervention.

Results: In the psyllium group the FBS, fasting insulin, total cholesterol, LDL-C, HOMA1-IR and HOMA2-IR indicators decreased significantly (P<0.05) after 8 weeks, but the changes were not significant in the placebo group. The mean changes in LDL-C (­0.28±0.58 in the intervention group and 0.11±0.67 in the placebo group, P=0.036) and QUICKI (0.01±0.03in the intervention group and ­0.02±0.06in the placebo group, P=0.044) were significant between the two groups from the baseline.

Conclusion: Psyllium supplementation decreased FBS, fasting insulin and the lipid profile and improved insulin resistance in non-diabetic women with PCOs.

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