|Oxidative Stress Markers in Early Pregnancy Loss: A Case-Control Study|
|Shahnaz Torkzahrani1, Padideh Janati Ataei1, Mehdi Hedayati2, Soheila Khodakarim3, Zohre Sheikhan1, Moniresadat Khoramabadi1, Akramsadat Sadraei4|
|1Department of Midwifery& Reproductive Health, School of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Cell and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Department of Epidemiology and Biostatistics, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Obstetrics and Gynecology, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Keywords : Oxidative Stress, Pregnancy, Spontaneous abortion
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Objectives: Evidence suggests that oxidative stress plays a role in the pathophysiology of pregnancy complications in women. The present study was conducted to determine the levels of oxidative stress markers in early pregnancy loss and to compare the results with those in healthy pregnant women.
Materials and Methods:A total of 32 women with early pregnancy loss and 32 healthy women in the first trimester of pregnancy and with similar demographic characteristics entered this study as the cases and controls. Serum levels of malondialdehyde (MDA), total antioxidant capacity (TAC) and uric acid and bilirubin levels were determined in both groups. The data obtained were then analyzed and compared between the groups using the independent-sample t‐test and Mann-Whitney’s U-test.
Results:The two groups were matching in terms of personal-demographic characteristics including mother’s age, father’s age, gravidity and body mass index(BMI). MDA levels increased significantly in the women with spontaneous abortion compared to the healthy pregnant women (4.35±1.47 vs. 3.42±1.68 µM/L; P=0.026) and TAC decreased significantly in the cases compared to the healthy controls(552.34±212.79 vs. 1003.23±1168.68 U/ml; P=0.040). Uric acid and bilirubin levels did not differ between the groups.
Conclusion: The results of this study provide further evidence on the effect of increased oxidative stress on the incidence of early spontaneous abortion in the first trimester of pregnancy. High serum MDA levels and low TAC during pregnancy were two risk factors for spontaneous abortion. The present findings support the hypothesis that oxidative stress plays a key role in the etiopathogenesis of spontaneous abortion. Further studies are required for assessing the preventive role of antioxidant therapy in this complication.
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