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Apr 2019, Vol 7, Issue 2
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Changes in Fetal Circulation After Maternal Corticosteroid Administration: Systematic Review
Sanaz Mousavi1, Simin Taghavi1, Fatemeh Abbasalizadeh1, Shabnam Vazifekhah2, Mohammad Naghavi-Behzad3
1Womens Reproductive Health Research Center,Tabriz University of Medical Sciences, Tabriz, Iran
2Maternal and Childhood Obesity Research Center,Urmia University of Medical Sciences, Urmia, Iran
3Students Research Committee,Tabriz University of Medical Sciences, Tabriz, Iran

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Keywords : Antenatal corticosteroids, Pregnancy, Umbilical artery pulsatility index, Middle cerebral artery pulsatility index
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Objectives: The article aims at reviewing the existing literature on the effects of maternal corticosteroids administration on umbilical artery and middle cerebral artery pulsatility index (PI).

Materials and Methods: The search for relevant materials on “evaluating the effect of corticosteroids on fetal circulation” included the followings databases: PubMed, Scopus, Cochrane Library, ISI Web of Science, Proquest, Google Scholar, EMBASE, and Iranian Databases of Magiran, Iran Medex, Barakat knowledge Network System, Scientific Information Database, Iranian Research Institute for Information Science and Technology, from ??? up to June of 2017.

Results: Following the search 19 articles were found to be relevant to the search topic. In total these studies included 654 pregnant women, who were evaluated for fetal circulation before and after corticosteroid (betamethasone or dexamethasone) injection, for umbilical artery and middle cerebral artery pulsatility index. The effects of steroid injection were evaluated between 23 and 34 weeks of gestation.

Conclusions: Overall the results of the reviewed studies indicated that, antenatal exposure to corticosteroids, reduces Umbilical artery PI and MCA PI and improves fetal circulation during pregnancy.

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