|Correlation of Maternal KIR and Parental HLA-C Genes Diversity with Risk of Preeclampsia in Lorestan Province of Iran|
|Soheila Akbari1, Seyyed Amir Yasin Ahmadi2, Farhad Shahsavar3, Khatereh Anbari4|
|1 Department of Obstetrics and Gynecology, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
3 Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran
4 Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
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Keywords : HLA-C, KIR, NK cells, Preeclampsia
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Objectives: Fetomaternal immune tolerance induced by Natural killer cells (NKs) is a necessary phenomenon associated with maternal killer-cell immunoglobulin-like receptors (KIR) and fetal human leucocyte antigens (HLA). We aimed to investigate maternal KIR, parental HLA-C, and maternal-parental KIR-HLA combination in both preeclampsia and control groups.
Materials and Methods: A number of 200 couples have participated in this case-control study. DNA samples were assayed through polymerase chain reaction with specific sequences of primers (PCR-SSP).
Results: For maternal KIR genes and genotypes and paternal HLA-C genes no significant difference was found between the cases and the controls. A significant relation was found for maternal KIR and paternal HLA-C combination. The relation was for the inhibitory combination KIR2DL1+HLA-C2 in the preeclampsia group (P<0.05; OR=2.02; sensitivity=79%). In addition, maternal AA genotype of KIR in combination with paternal HLA-C1C2 was a risk factor (P<0.05; OR=3.24; specificity=92%).
Conclusion: The inhibitory maternal-paternal combinations KIR2DL1+HLA-C2 and AA+HLA-C1C2 seem to be associated with risk of preeclampsia. Prediction of preeclampsia with help of cohort studies can be possible in future.
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