|Association of Basal Anti-Mullerian Hormone and its Changes with Ovarian Response and Pregnancy in Polycystic Ovary Syndrome Patients in ovulation Induction Cycles|
|Nayereh Ghomian, Marzieh Lotfalizadeh, Malihe Afiat, Farideh Golhasani Keshtan|
|Department of Obstetrics and Gynecology ,Mashhad University of Medical Sciences, Mashhad, Iran|
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Keywords : Anti-Mullerian Hormone, Polycystic Ovary Syndrome, Ovulation Induction, Infertility, Letrozole
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Objective: One of the causes of infertility is Polycystic Ovary Syndrome (PCOS).Anti-Mullerian Hormone (AMH) is 2-3 times higher in patients with PCOS compared to others.The purpose of this study was to survey the association of basal AMH levels with ovarian response in infertile PCOS patients.
Methods: In this cross-sectional study, 70 infertile PCOS women who referred to Milad Infertility Center, Mashhad, Iran from May 2011 to April 2012 were enrolled. The basal blood level of AMH was evaluated. The patients received 5 mg of letrozole for five days from the 5th cycle day and then received 150 units gonal F in the form of therecombinant Follicle-Stimulating Hormoneon the 9th day of the cycle. Five thousand units of Human Chorionic Gonadotropinwere prescribed in the patients who had one follicle of ≥18mm, and they should have coitus at 36 hr later. On the 10th cycle day, after ovulation induction, the second serum sample for AMH was taken.
Results: Changes of AMH did not have a significant relationship with the ovarian response, and it was lower in patients with positive ovarian response compared to patients without ovarian response.The basal level of AMH in patients with apositive ovarian response (3.91±2.14) did not have a significant difference with the secondary AMH (3.27±2.39) after the ovulation induction(p=0.19).
Conclusion: AMH was not the predictor of ovarian response in PCOS patients, and the amount of AMH was reduced after treatment. This effect may have a relationship with letrozole and gonadotropin.
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