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Apr 2018, Vol 6, Issue 2
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Original Article
Effect of Different Doses of Paracetamol on Postoperative Pain after Gynecologic Laparoscopy
Simin Atashkhoei1, Fariba Nikan2, Reza Kardan3, Hojjat Pourfathi4
1Department of Anesthesiology, Al-Zahra Hospital, Tabriz University of Medical Sciences, Iran
2Department of Anesthesiology, Taleghani Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Anesthesiology, Taleghani Hospital, Tabriz University of Medical Sciences, Tabriz,Iran
4Department of Anesthesiology, Taleghani Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

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Keywords : Gynecologic surgery, Laparoscopy, Postoperative pain, Paracetamol
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Objectives: This study aimed to investigate the analgesic efficacy and safety of preventive administration of 2 g compared with 1 g of paracetamol for the management of postoperative pain in patients undergoing gynecologic laparoscopic procedures.

Methods and Materials: This double-blind study was conducted on 92 women who were randomized to two groups: paracetamol 2 g (study group; n=46) or 1 g (control group; n=46) into 100 mL normal saline, infused over 15 min end of surgery. Abdominal and shoulder pain scores were recorded in PACU and 1, 2, 3, 6, 12, and 24 h after the operation. The time of first request for analgesic and the values of liver enzymes were recorded.

Results: During 24 h after surgery, the prevalence of postoperative abdominal pain was 52.17% and 89.13% (P <0.001) and shoulder pain was 6.52% and 23.91% (P =0.039) in study and control group, respectively. Abdominal pain score (0.06±0.32 vs. 1.6±2.0; P <0.001) and shoulder pain score (0.0 ± 0.0 vs. 0.50±1.37; P =0.017) in PACU were lower in study group compared control group. The time to first request for analgesic was significantly longer study group than control group (P = 0.030). There was no significant difference in liver enzyme values in postoperative 24 h between groups (P > 0.05).

Conclusion: Administration of both does of paracetamol at the end of surgery was effective for postoperative pain; However, the best pain relief was obtained by 2 g paracetamol with no side effects.

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