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Jul 2018, Vol 6, Issue 3
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Original Article
Comparing Misoprostol Vs. Oxytocin Injection in Umbilical Vein for Managing Retained Placenta after Parturition: A Randomized Clinical Trial
Aida Najafian1, Marzieh Ghasemi2, Neda Hajiha-Esfahani3
1Department of Endocrinology and Infertility,Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Department of Obstetrics and Gynecology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
3Department of Obstetrics and Gynecology, Moheb-Yass Hospital, Tehran University of Medical Sciences, Tehran, Iran

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Keywords : Retained placenta, Misoprostol, Oxytocin, Umbilical vein
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Objectives: Retained placenta in the third stage of parturition causes complications that may threaten a mother’s life. In this clinical trial we comparedinjecting misoprostol and oxytocin in the umbilical vein for managingretained placenta inwomen who had referred toourhospitals in Tehran andBandarabascities, Iran.

Materials and Methods: Between 2012 and 2015, 44 womenwith a long third stage of parturition (retained placenta for more than 30 minutes) were chosen for this study. They were randomly divided into two groups:oxytocin and misoprostol groups (22 women in each group).In oxytocin group, oxytocin was injected into the umbilical vein with 50-unitconcentration in 30 mL of normal saline. In misoprostol group,800 µg of misoprostol was injected into the umbilical vein in 30 mL of normal saline. Placenta delivery times, bleeding after parturition and hemoglobin drop were compared betweenthe two groups.

Results: There was no significant difference between injecting misoprostol or oxytocin in the umbilical vein regarding spontaneous placenta egression in mothers younger than 30 years old. Spontaneous placenta egression was significantly more in misoprostol group. This was magnified among women who were pregnant for more than 30 weeks.

Conclusion: Injecting misoprostol inthe umbilical vein is more effective than injecting oxytocin in managing retained placenta in the third stage of parturition.

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