|In Vitro Fertilization Success and Associated Factors: A Prospective Cohort Study|
|Azra Azmoudeh1, Zahra Shahraki2, Fatemeh-Sadat Hoseini3, Firoozeh Akbari-Asbagh3, Fatemeh Davari-Tanha4, Forough Mortazavi4|
|1Department of Obstetrics and Gynecology, Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Department of Obstetrics and Gynecology, Zabol University of Medical Sciences, Zabol, Iran
3Department of Obstetrics and Gynecology, Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran
4Department of Midwifery, School of Nursing & Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran
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Keywords : Infertility, fertilization in vitro, Embryo research, Anti mullerian hormone, Iran
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Objective: IVF success depends on many factors which their independent roles have not been fully investigated. The aim of this study was to evaluate the role of factors in women undergoing in vitro fertilization (IVF) in Iran.
Materials and Methods: In a prospective cohort study, one hundred and sixty women who referred to Moheb-Yas hospital infertility center for IVF between March 2015 and March 2016 were enrolled. A long ovarian stimulation protocol was administered using a gonadotropin-releasing hormone agonist (GnRH). Anti-Mullerian Hormone (AMH), progesterone, estradiol, and endometrial thickness were measured. Two expert embryologists categorized blastocysts as good or poor. Pregnancy was judged by serum human chorionic gonadotropin measurement 14–15 days after embryo transfer.
Results: Mean age of cases was 32 years and mean body mass index (BMI) was 20 kg/m2. Clinical pregnancy rate was 20.6%. A significant relationship was found between IVF success and AMH, the number of FSH injections, endometrial thickness, embryos’ grade, and the number of embryos produced. Logistic regression analysis showed that only AMH > 0.6 was an independent predictor of IVF success (OR = 6.22, CI [2.4-16.2]). Further analysis showed a significant relationship between AMH level and IVF success in women ≤ 35.
Conclusion: The overall success rate of IVF/ET was 20.6%. AMH is a significant predictor of IVF success and may be an important factor in IVF success in young women.
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