|Evaluation of Medroxyprogesterone Acetate Compared with Cetrotide For Preventing Premature Luteinizing Hormone Surges in Women Undergoing For In Vitro Fertilization|
|Hamdi Kobra1, Farzadi Laya1, Ghasemzadeh Alea1, Navali Nazli1, Atashkhoei Simin1, Pia Helen1, Shahnazi Vahedeh1, Fattahi Amir2, Bahrami-asl Zahra1 , Sepasi Farnaz1, Dopour Faliz Massomeh1, Lahroudi Nahid1, Hakimi Parvin1|
|1Womens Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords : Medroxyprogesterone acetate, Ovarian stimulation, Premature LH surge
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Objective: The aim of the study was to investigate effects of medroxyprogesterone acetate (MPA) in a prevention of LH surge during controlled ovarian hyper stimulation (COH).Characteristics of cycle and pregnancy outcomes compared in subsequently frozen-thawed embryo transfer (FET)cycles.
Materials and methods: In a prospective controlled study, IVF/intracytoplasmic sperm injection treatment was done in ninety-nine patients. In the case group, hMG and MPA administered from 3rd day of the cycle, simultaneously. As dominant follicles matured, ovulation induced by hCG or GnRH agonist.In the control group, hMG and GnRH administrated. For later transfer in both protocols, viable embryos cryo preserved. The primary outcome measure was the incidence of premature LH surge and amount of oocytes retrieved. Clinical pregnancy outcomes from FETs were secondary outcomes.
Results: A number of oocytes retrieved were similar in both case and control group. LH suppression persisted during ovarian stimulation in case group, and there was no incidence of premature LH surge. There was no significant difference between amounts of follicles, mature follicles, oocyte and resumed obtained embryos between two groups (p>0.05).
Conclusion: The results show that in a woman undergoing COH, the MPA is an effective oral drug in the prevention of premature LH surge. The results will help to establish a new method for ovarian stimulation in combination with embryo cryo preservation.
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