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Apr 2018, Vol 6, Issue 2
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Original Article
Comparison of Medroxyprogesterone Acetate With Cetrotide for Prevention of Premature Luteinizing Hormone Surges in Women Undergoing In Vitro Fertilization
Kobra Hamdi1, Laya Farzadi1, Alea Ghasemzadeh1, Nazli Navali1, Simin Atashkhoei1, Helen Pia1, Vahedeh Shahnazi1, Amir Fattahi2, Zahra Bahrami-asl1, Farnaz Sepasi1, Massomeh Dopour Faliz1, Nahid Lahroudi1, Parvin Hakimi1
1Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

IJWHR 2018; 6: 187-191
DOI: 10.15296/ijwhr.2018.31
Viewed : 833 times
Downloaded : 551 times.

Keywords : Medroxyprogesterone acetate, Controlled ovarian stimulation, Premature LH surge
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Abstract
Objectives: The aim of the study was to investigate the role of medroxyprogesterone acetate (MPA) in the prevention of luteinizing hormone (LH) surge during controlled ovarian hyperstimulation (COH). Characteristics of cycle and pregnancy outcomes were compared in subsequent frozen-thawed embryo transfer (FET) cycles.

Materials and Methods: In a prospective controlled study, In vitro fertilization (IVF)/intracytoplasmic sperm injection treatment was done in 99 patients. In the case group, hMG and MPA were administered from third day of the cycle, simultaneously. As dominant follicles matured, ovulation was induced by hCG or GnRH agonist. hMG and GnRH were administrated to the control group. For later transfer in both protocols, viable embryos were cryopreserved. The primary outcome measured was the incidence of premature LH surge and a number of oocytes retrieved. Clinical pregnancy outcomes from FETs were secondary outcomes.

Results: The number of oocytes retrieved in both case and control groups were equal. LH suppression persisted during ovarian stimulation in the case group, and there was no incidence of premature LH surge. There was no significant difference between amounts of follicles, mature follicles, oocytes resumed and obtained embryos between 2 groups (P > 0.05).

Conclusions: The results showed that in a woman undergoing COH, MPA as an oral drug was effective in the prevention of premature LH surge. The results would help to establish a new method for ovarian stimulation in combination with embryo cryopreservation.

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Articles by Hamdi K
Articles by Farzadi L
Articles by Ghasemzadeh A
Articles by Navali N
Articles by Atashkhoei S
Articles by Pia H
Articles by Shahnazi V
Articles by Fattahi A
Articles by Bahrami-asl Z
Articles by Sepasi F
Articles by Dopour Faliz M
Articles by Lahroudi N
Articles by Hakimi P

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Articles by Kobra Hamdi
Articles by Laya Farzadi
Articles by Alea Ghasemzadeh
Articles by Nazli Navali
Articles by Simin Atashkhoei
Articles by Helen Pia
Articles by Vahedeh Shahnazi
Articles by Amir Fattahi
Articles by Zahra Bahrami-asl
Articles by Farnaz Sepasi
Articles by Nahid Lahroudi
Articles by Parvin Hakimi

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