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Apr 2018, Vol 6, Issue 2
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Original Article
The Effect of Letrozole and Metformin on Endometrial Histology in Patients with Disordered Proliferative Endometrium
Elaheh Ouladsahebmadarek , Leila Balali, Manizheh Sayyah-Melli, Mehri Jafari Shobeiri, Parvin Mostafa Gharabaghi, Ali Dastranj Tabrizi, Maryam Noushinvahidi, Behnaz Najafnejad
Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences,Tabriz, Iran


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Keywords : Abnormal Uterine Bleeding,Letrozole, Metformin, Disordered Proliferative Endometrium
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Abstract
Objective: To explore whether letrozole and metformin can change endometrial histology in patients diagnosed with disordered proliferative endometrium.

Materials and Methods: In a before - after interventional study , 31 patients with abnormal uterine bleeding were selected to receive 5 mg of letrozole and 500 mg metformin daily for 3 months after pathology report of disordered proliferative endometrium.The effect of this combination on endometrial histology was evaluated through comparing the endometrial histologies before and after the intervention.

Results: After treatment with letrozole and metformin, 77.4% of patients showed significant response to therapy in the form of inactive and atrophic endometrium (P value < 0.001). The clinical response to treatment was observed in 18 (58.1%) women as complete relief of bleeding or decreased hemorrhage in 6 (19.4%) women.

Conclusion: Based on the results of this study,letrozole and metformin can be successfully used for treatment of disordered proliferative endometrium. So, the effects of these medications deserve to be noticed for conservative treatment of patients with abnormal uterine bleeding.

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