|Polycystic Ovary Syndrome (PCOS) Is Affected and Protected by DD and DI Genotypes of Angiotensin Converting Enzyme (ACE) respectively: An Update of a Meta-Analysis|
|Fatemeh Yari1, Kamran Aeinfar2, Saber Abbaszadeh3, Khatereh Anbari4, Seyyed Amir Yasin Ahmadi3|
|1School of Nursery and Midwifery, Lorestan University of Medical Sciences, Khorramabad, Iran
2Rajaei Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
3Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
4Department of Community Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
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Keywords : polycystic ovary syndrome, angiotensin converting enzyme, meta-analysis
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Objective: Angiotensin converting enzyme (ACE) is an important enzyme involving in renal and cardiovascular systems physiopathology, as well as in ovary. One of these ACE related diseases is polycystic ovary syndrome (PCOS). We intend to update the only meta-analysis written by Jia et al. in 2013 about the association of ACE gene polymorphism and risk of PCOS. The reason of our attempt to update this meta-analysis was that they found no significant relation in their meta-analysis.
Materals and methods: For this aim, we searched in databases for relevant documents. Finally we found 8 relevant papers that 6 of them had been covered by that meta-analysis of Jia's et al. In order to perform this meta-analysis, we used comprehensive meta-analysis software. The analysis was done through P value and sample size of each study based on fixed-effect model. Analyses performed in five different groups of alleles and genotypes.
Results: Among these five analyses, four of them were statistically significant. Hereby we concluded that DD genotype of ACE is a risk factor for PCOS (P value = 0.013; odds ratio = 1.195), while DI is the protecting genotype (P = 0.009; OR = 0.819).
Conclusion: Hence it is suggested to use a very low dose of captopril as an ACE inhibitor in the PCOS patients having DD genotype in future as a clinical trial, just as a scientific model. Further investigations on ovary ACE system is needed.
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