|Maternal Magnesium Level Effect on Preterm Labor Treatment|
|Marzieh Lotfalizadeh, Nayereh Ghomian, Salmeh Dadgar, Faezah Halimi|
|Mashhad University of Medical Sciences, department of Obstetrics and Gynecology, mashhad, Iran|
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Keywords : Maternal magnesium, preterm labor
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Objective: compare the serum magnesium level in women with preterm labour, withits level in women withnormal pregnancy of the same age, assess the relation between serum magnesium level and response to MgSO4.
Method: Fortywomen aged18-40, gestation age of 26-32 weeks with signs of preterm labour and fortywomen in similar age and gestation age with normal pregnancy were included. Case group received Betametason 12 mg in two separate doses with 24 h interval. MgSO4 was administrated (dose of 4 mg), and continued by 2mg/h. Once thetocolytic therapy goal was achieved, the administration of MgSO4 continued for an additional 12 hours.
Results: The mean age, gestational age, gravidity, parity, number of live children, number of dead children, miscarriage and mole pregnancy was similar in thetwo groups. The mean of serum magnesium level showed significant difference between two groups. In case group,27 patients hadpositivetherapeutic response to MgSO4: the difference between mean of serum magnesium level in these 27 patients and the other 13 patients who did not respond well was significant. The serum magnesium < 1.85 mg/dl as cutoff point had 85% sensitivity and 78% specificity with CI= 0.75-0.97 in predicting response to MgSO4 in case group.
Conclusion: Serum magnesium level can be used as a predictive tool for preterm labour. It can help in preterm labour to select patients who benefit from MgSO4 as tocolytic therapy. Magnesium supplementation may be helpful in patients with decreased serum magnesium level to prevent preterm labour.
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