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Jan 2018, Vol 6, Issue 1
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Original Article
Comparison of Cesarean Section and Natural Vaginal Delivery Using Entonox Inhalation in Terms of Oxidative Stress Indices in Newborns and Mothers
Katayon Vakilian, Akram Ranjbar
Department of Nursing Midwifery School, Arak university of Medical Sciences, Arak, Iran

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Keywords : Oxidative stress, Cesarean section, Entonox, Newborn
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Objective: Review of articles point out the route of delivery could create oxidative stress. Since provision of safe labor is of great importance for healthy child bearing , the present study was performed to compare cesarean section and natural vaginal delivery through Entonox inhalation in terms of oxidative stress indices in mode of delivery.

Materials and Methods: 60 women undergoing cesarean section(CS) and 60 going through painless labor using Entonox gas were included after obtaining a written informed consent. Three tests, including lipid peroxidation, total thiol molecules(TTM), and ferric reducing ability of plasma (FRAP) assay, were performed after taking 5 cc venous blood sample from the mothers at the end of the second labor phase or after surgery. The same indices were measured in 5 cc blood taken from the umbilical artery of the infants. Descriptive (means) and analytical (independent t-test) tests were employed for data analysis.

Results: Mean maternal lipid peroxidation level in the CS and Entonox groups were 5.798±4.210 and 5.105±2.892 nμ/mm, respectively (P=0.544). The total thiol molecules(TTM) were 0.2846±0.2632 and 0.2656±0.2437 mμ/mm in the CS and Entonox groups (P=0.687). Moreover, mean scores of FRAP were 0.766±0.516 and 1.057±0.626 nμ/mm in the CS and Entonox groups, respectively (P=0.007). However, oxidative stress indices of the infants were not different between the two groups (P>0.05).

Conclusion: Since total antioxidant capacity in the CS group was lower compared to the Entonox group, it seems that maternal antioxidant defense decreases. Thus, Entonox can be used safely from the perspective of oxidative stress indices.

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