|Protective Effect of Matricaria chemmomilla Extract on Histological Damage and Oxidative Stress Induced by Torsion / Detorsion in Adult Rat Ovarian|
|Soltani M1, Moghimian M1, Abtahi Evari S.H1, Shokoohi M2|
|1Department of Basic Sciences, faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
2Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran
2Department of Anatomical Sciences, faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords : Torsion/detorsion, Tissue damage, Oxidative stress, Chemmomilla, Ovarian
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Objective: This experimental study used a rat model to investigate the effect of an extract of Matricaria chemmomilla on histological damage and oxidative stress induced by torsion / detorsion in adult rat ovary.
Materials and methods: in our experimental study, were used 28 female Wistar rat. They randomly divided into 4 groups; G1, Sham group; G2, Ovarian torsion for 3 hours followed by detorsion 10 day(TDO); G3, Ovarian torsion for 3 hours and receiving 200 mg/kg hydroalcholic extracts of MC, 30min before detorsion and followed by detorsion (10 day) (TDOMC); G4, receiving 200 mg/kg hydroalcholic extracts of MC(MC) After the reperfusion period, 10 day, and their blood sampling, blood levels of estrogen, testosterone, some oxidative stress markers and anti-oxidant enzymes were assayed. Further assessment was carried out by histomorphometry at 10day post procedure.
Results: Comparison of The histological parameters showed a significant change in the G2 group as compared with other groups. The levels of estrogen, GPX, and superoxide dismutase significantly decreased in G2 group, and increased in G3 and G4 groups, and the malondialdehyde level increased in the duration of ischemia increased. Treatment by MC decreased the malondialdehyde level in G3and G4 groups.
Conclusions: The results of this study showed that Matricaria chemmomilla could be reduced oxidative stress and tissue damages following ovarian torsion/detorsion.
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